Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.40 |
| ▸ | LOX | P28300 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 3/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814142 | 0.90 | KDM5A (0.35) | TRPA1GRM2KDM5AKDM5BKDM4C | |
| SCHEMBL6814145 | 0.86 | TRPA1 (0.52) | TRPA1EPHX2MMP13 | |
| SCHEMBL6819195 | 0.85 | LOXL2 (0.40) | LOXL2LOXTRPA1GRM2KDM5A | |
| SCHEMBL6484565 | 0.84 | RXRA (0.35) | TRPA1KDM5AKDM5B | |
| SCHEMBL6819189 | 0.75 | KDM5A (0.37) | GRM2KDM5AKDM5BKDM4C | |
| SCHEMBL6819192 | 0.74 | MMP13 (0.41) | TRPA1EPHX2MMP13 | |
| SCHEMBL6476858 | 0.72 | TRPA1 (0.49) | TRPA1 | |
| SCHEMBL6485426 | 0.70 | P2RY14 (0.36) | KDM5AKDM5B | |
| Picolamine SCHEMBL6818607 | 0.68 | PLA2G7 (0.34) | TRPA1PLA2G7 | |
| SCHEMBL6476888 | 0.67 | RXRA (0.35) | KDM5AKDM5BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014908-A1 | HETEROBICYLCIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |