Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | AIP | O00170 | 1/20 | 0.50 |
| ▸ | SGTA | O43765 | 1/20 | 0.50 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.50 |
| ▸ | STIP1 | P31948 | 1/20 | 0.50 |
| ▸ | PPP5C | P53041 | 1/20 | 0.50 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.50 |
| ▸ | PPID | Q08752 | 1/20 | 0.50 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.50 |
| ▸ | FKBP8 | Q14318 | 1/20 | 0.50 |
| ▸ | TOMM34 | Q15785 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288773 | 0.83 | MAPT (0.61) | ALDH1A1MAPTLMNAPOLBHTT | |
| SCHEMBL3918756 | 0.82 | ALDH1A1 (0.70) | ALDH1A1MAPTLMNAPOLBHTT | |
| SCHEMBL3922647 | 0.77 | MAPT (0.59) | ALDH1A1MAPTHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6437855 | 0.75 | ALDH1A1 (0.58) | ALDH1A1MAPTLMNAPOLBHTT | |
| SCHEMBL3921443 | 0.73 | GAA (0.63) | ALDH1A1MAPTLMNAPOLBHTT | |
| SCHEMBL1520529 | 0.73 | POLB (0.63) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL14586394 | 0.73 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL3914838 | 0.71 | GAA (0.76) | ALDH1A1MAPTLMNAPOLBHTT | |
| SCHEMBL8289416 | 0.71 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL3278975 | 0.69 | ALDH1A1 (0.78) | ALDH1A1MAPTLMNAPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2011-11-10 | — | — | US | disclosed |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2010-04-08 | — | — | US | disclosed |
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | ONPHARM GMBH (CH) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 174/4885MAPT 4299/4885LMNA 4114/4885 |
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | MMP1, MMP11, HSD11B2 | ALDH1A1 248/4885MAPT 3726/4885LMNA 2566/4885 |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | MMP1, HSD11B1, HSD11B2 | ALDH1A1 241/4885MAPT 3637/4885LMNA 2410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.