Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818927 | 1.00 | CTSL (0.43) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6818865 | 0.86 | ITGB3 (0.47) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6814340 | 0.83 | CTSS (0.42) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6814338 | 0.83 | CTSS (0.42) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6815409 | 0.81 | MMP9 (0.45) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6815411 | 0.81 | MMP9 (0.45) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6818706 | 0.80 | HPN (0.45) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6819854 | 0.80 | MMP2 (0.51) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6819859 | 0.80 | MMP2 (0.51) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL6818700 | 0.80 | HPN (0.45) | CTSLCTSSCTSKMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004020402-A1 | SULPHONYLAMINO DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | claimed |
| WO-2004020402-A1 | SULPHONYLAMINO DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | disclosed |