Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | XIAP | P98170 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828866 | 0.83 | NPSR1 (0.42) | HPGDALDH1A1CYP2C9CYP2C19ROCK1 | |
| SCHEMBL6828337 | 0.80 | CHEK1 (0.40) | HPGDPTGS1XIAPALDH1A1HSP90AA1 | |
| SCHEMBL6825993 | 0.79 | ADORA3 (0.45) | HPGDPTGS1XIAPALDH1A1HSP90AA1 | |
| SCHEMBL8067393 | 0.78 | KMT2A (0.48) | HPGDPTGS1XIAPALDH1A1CYP2C9 | |
| SCHEMBL6828786 | 0.77 | HPGDS (0.49) | HPGDALDH1A1CYP2C9CYP2C19MEN1 | |
| SCHEMBL6829284 | 0.76 | MAPK8 (0.43) | HPGDMEN1KMT2ACDK2ADORA2A | |
| SCHEMBL6830646 | 0.76 | ADORA2A (0.53) | HPGDXIAPALDH1A1MEN1KMT2A | |
| SCHEMBL6828438 | 0.76 | L3MBTL1 (0.43) | ROCK2SMN1; SMN2 | |
| SCHEMBL6825783 | 0.76 | ADORA1 (0.56) | HPGDXIAPALDH1A1MEN1KMT2A | |
| SCHEMBL6828357 | 0.75 | ADORA2A (0.51) | XIAPKMT2AADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |