Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828721 | 0.84 | MET (0.44) | NPSR1SMN1; SMN2MAPTTP53RXFP1 | |
| SCHEMBL6829256 | 0.83 | HPGD (0.39) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6133795 | 0.77 | NPSR1 (0.42) | NPSR1SMN1; SMN2MAPTTP53RXFP1 | |
| SCHEMBL6828337 | 0.74 | CHEK1 (0.40) | NPSR1MAPTALDH1A1PDGFRBAURKB | |
| SCHEMBL6825993 | 0.73 | ADORA3 (0.45) | SMN1; SMN2TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL6828483 | 0.73 | XIAP (0.44) | NPSR1SMN1; SMN2MAPTTP53RXFP1 | |
| SCHEMBL6830646 | 0.72 | ADORA2A (0.53) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6825783 | 0.72 | ADORA1 (0.56) | MAPTALDH1A1MEN1KMT2AADORA3 | |
| SCHEMBL6828357 | 0.71 | ADORA2A (0.51) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL6828894 | 0.71 | SMN1; SMN2 (0.44) | NPSR1SMN1; SMN2RXFP1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |