SCHEMBL6829615

SCHEMBL6829615

O=Cc1ccc(COc2ccccc2)o1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
TSHR P16473 2/20 0.50
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
POLB P06746 2/20 0.43
HSD17B10 Q99714 2/20 0.43
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
NPC1 O15118 7/20 0.43
RAB9A P51151 7/20 0.43
MAPT P10636 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
KMT2A Q03164 2/20 0.43
TP53 P04637 1/20 0.43
MDM2 Q00987 1/20 0.43
RXFP1 Q9HBX9 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6923514 0.83 ALDH1A1 (0.47) ALDH1A1TSHRPOLBKDM4ELMNA
SCHEMBL7132970 0.83 SMN1; SMN2 (0.51) ALDH1A1TSHRPOLBHSD17B10KDM4E
SCHEMBL6829232 0.83 NPC1 (0.50) ALDH1A1TSHRCYP1A2CYP3A4CYP2C9
SCHEMBL6926049 0.83 HSD17B10 (0.57) ALDH1A1TSHRCYP1A2CYP2C9CYP2C19
SCHEMBL6919445 0.80 MAOB (0.44) ALDH1A1TSHRNPC1RAB9AKMT2A
SCHEMBL7133523 0.80 NPC1 (0.60) ALDH1A1TSHRCYP1A2CYP2C9CYP2C19
SCHEMBL6831252 0.79 ALDH1A1 (0.46) ALDH1A1TSHRCYP1A2CYP3A4CYP2C9
SCHEMBL22289462 0.78 TSHR (0.50) ALDH1A1TSHRPOLBKDM4ELMNA
SCHEMBL278333 0.77 ALDH1A1 (0.61) ALDH1A1TSHRCYP3A4CYP2C9CYP2C19
SCHEMBL6441520 0.76 DAO (0.49) ALDH1A1TSHRPOLBHSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12459929-B2 GPCR receptor agonists, pharmaceutical compositions comprising the same, and methods for their use CARMOT THERAPEUTICS INC. (US) 2025-11-04 US disclosed
EP-4563199-A2 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE Carmot Therapeutics, Inc. (US) 2025-06-04 EP disclosed
US-20250154137-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE CARMOT THERAPEUTICS, INC. 2025-05-15 US disclosed
US-20240252492-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE CARMOT THERAPEUTICS, INC. 2024-08-01 US disclosed
EP-4284795-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE Carmot Therapeutics, Inc. (US) 2023-12-06 EP disclosed
CN-117043154-A GPCR receptor agonists, pharmaceutical compositions comprising same, and methods of use thereof 卡莫特医疗有限公司 2023-11-10 CN disclosed
US-20230089073-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE CARMOT THERAPEUTICS, INC. 2023-03-23 US disclosed
WO-2022165076-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE CARMOT THERAPEUTICS, INC. (US) 2022-08-04 WO disclosed
US-11319292-B2 Metabolically stable 5-HMF derivatives for the treatment of hypoxia KING ABDULAZIZ UNIVERSITY (SA) 2022-05-03 US disclosed
US-11319292-B2 Metabolically stable 5-HMF derivatives for the treatment of hypoxia KING ABDULAZIZ UNIVERSITY (SA) 2022-05-03 US disclosed
US-11149012-B1 Metabolically stable 5-HMF derivatives for the treatment of hypoxia KING ABDULAZIZ UNIVERSITY (SA) 2021-10-19 US disclosed
US-11149012-B1 Metabolically stable 5-HMF derivatives for the treatment of hypoxia KING ABDULAZIZ UNIVERSITY (SA) 2021-10-19 US disclosed
US-10875834-B2 Prodrug and protected forms of 5-hydroxymethylfurfuranal (5-HMF) and its derivatives VIRGINIA COMMONWEALTH UNIVERSITY (US) 2020-12-29 US disclosed
US-10836729-B1 Metabolically stable 5-HMF derivatives for the treatment of hypoxia KING ABDULAZIZ UNIVERSITY (SA) 2020-11-17 US disclosed
US-10836729-B1 Metabolically stable 5-HMF derivatives for the treatment of hypoxia KING ABDULAZIZ UNIVERSITY (SA) 2020-11-17 US disclosed
US-20190256483-A1 PRODRUG AND PROTECTED FORMS OF 5-HYDROXYMETHYLFURFURANAL (5-HMF) AND ITS DERIVATIVES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2019-08-22 US disclosed
EP-3490980-A1 PRODRUG AND PROTECTED FORMS OF 5-HYDROXYMETHYLFURFURANAL (5-HMF) AND ITS DERIVATIVES Virginia Commonwealth University (US) 2019-06-05 EP disclosed
WO-2018018035-A1 PRODRUG AND PROTECTED FORMS OF 5-HYDROXYMETHYLFURFURANAL (5-HMF) AND ITS DERIVATIVES VIRGINIA COMMONWEALTH UNIVERSITY (US) 2018-01-25 WO disclosed
WO-2018018035-A1 PRODRUG AND PROTECTED FORMS OF 5-HYDROXYMETHYLFURFURANAL (5-HMF) AND ITS DERIVATIVES VIRGINIA COMMONWEALTH UNIVERSITY (US) 2018-01-25 WO disclosed
WO-2004037808-A1 2 - SUBSTITUTED HETEROCYCLIC COMPOUNDS AND ANTITUMOR COMPOSITION COMPRISING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2004-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11149012-B1 Metabolically stable 5-HMF derivatives for the treatment of hypoxia HIF1AN, HMOX2, HIF1A ALDH1A1 307/4885TSHR 3524/4885CYP1A2 765/4885
US-20250154137-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE GLP1R, GCGR, GIPR ALDH1A1 3497/4885TSHR 211/4885CYP1A2 2662/4885
US-10836729-B1 Metabolically stable 5-HMF derivatives for the treatment of hypoxia HIF1AN, HMOX2, HIF1A ALDH1A1 307/4885TSHR 3524/4885CYP1A2 765/4885
US-10875834-B2 Prodrug and protected forms of 5-hydroxymethylfurfuranal (5-HMF) and its derivatives MTHFD1, MTHFD2, ADH5 ALDH1A1 27/4885TSHR 2756/4885CYP1A2 105/4885
US-20230089073-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE GLP1R, GCGR, GIPR ALDH1A1 3497/4885TSHR 211/4885CYP1A2 2662/4885
US-20240252492-A1 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE GLP1R, GCGR, GIPR ALDH1A1 3497/4885TSHR 211/4885CYP1A2 2662/4885
US-12459929-B2 GPCR receptor agonists, pharmaceutical compositions comprising the same, and methods for their use GLP1R, GCGR, GIPR ALDH1A1 3497/4885TSHR 211/4885CYP1A2 2662/4885
US-11319292-B2 Metabolically stable 5-HMF derivatives for the treatment of hypoxia HIF1AN, HMOX2, HIF1A ALDH1A1 307/4885TSHR 3524/4885CYP1A2 765/4885
US-20190256483-A1 PRODRUG AND PROTECTED FORMS OF 5-HYDROXYMETHYLFURFURANAL (5-HMF) AND ITS DERIVATIVES MTHFD1, MTHFD2, ADH5 ALDH1A1 27/4885TSHR 2756/4885CYP1A2 105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.