Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16370623 | 0.72 | MEN1 (0.56) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL16370882 | 0.72 | CYP1A2 (0.47) | ALDH1A1HPGDHSD17B10USP2MAPK1 | |
| SCHEMBL16370718 | 0.72 | SMN1; SMN2 (0.50) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL2983863 | 0.71 | CHRNB2 (0.43) | CHRNB2CHRNA4KCNH2 | |
| SCHEMBL16371130 | 0.71 | SMN1; SMN2 (0.49) | KDM4EALDH1A1HSD17B10HTTTSHR | |
| SCHEMBL16370936 | 0.71 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL16371037 | 0.71 | KMT2A (0.51) | KDM4EALDH1A1HSD17B10HTTTSHR | |
| Hydrochloric Acid SCHEMBL16371043 | 0.71 | FKBP1A (0.49) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6832887 | 0.71 | TSHR (0.65) | KDM4EALDH1A1TSHRUSP2MAPK1 | |
| SCHEMBL16370596 | 0.69 | SMN1; SMN2 (0.51) | ALDH1A1HPGDHSD17B10HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |