Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844870 | 0.93 | EGFR (0.38) | METAP2ALDH1A1KDM4ELMNADRD2 | |
| SCHEMBL6844867 | 0.82 | TSHR (0.32) | METAP2 | |
| SCHEMBL1648737 | 0.78 | METAP2 (0.46) | METAP2ALDH1A1KDM4ELMNADRD2 | |
| SCHEMBL6844851 | 0.75 | ALDH1A1 (0.32) | METAP2ALDH1A1MAOB | |
| SCHEMBL6844872 | 0.74 | CA1 (0.36) | ALDH1A1 | |
| SCHEMBL6844864 | 0.72 | QRFPR (0.36) | — | |
| SCHEMBL1648420 | 0.71 | METAP2 (0.42) | METAP2ALDH1A1KDM4ELMNADRD2 | |
| SCHEMBL6844927 | 0.67 | TARBP2 (0.32) | ALDH1A1 | |
| SCHEMBL6844858 | 0.66 | TSHR (0.34) | ALDH1A1LMNA | |
| SCHEMBL6844919 | 0.65 | POLB (0.34) | ALDH1A1LMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |