Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844879 | 0.91 | POLB (0.36) | CYP2D6LMNAALDH1A1POLBKMT2A | |
| SCHEMBL6844855 | 0.87 | TSHR (0.32) | TSHRHSD17B10CYP2D6ALDH1A1CA12 | |
| SCHEMBL6844910 | 0.79 | HTR6 (0.32) | TSHRHSD17B10ALDH1A1TDP1KMT2A | |
| SCHEMBL6844919 | 0.78 | POLB (0.34) | CYP2D6LMNAALDH1A1POLBKMT2A | |
| SCHEMBL6844851 | 0.77 | ALDH1A1 (0.32) | ALDH1A1POLB | |
| SCHEMBL6844867 | 0.73 | TSHR (0.32) | TSHR | |
| SCHEMBL6844927 | 0.73 | TARBP2 (0.32) | ALDH1A1 | |
| SCHEMBL6844920 | 0.73 | ELANE (0.34) | TSHRHSD17B10LMNAALDH1A1CA12 | |
| SCHEMBL6844881 | 0.70 | CA1 (0.38) | HSD17B10ALDH1A1CA12CA2CA9 | |
| SCHEMBL1648374 | 0.70 | METAP2 (0.40) | TSHRHSD17B10CYP2D6ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |