Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006818 | 0.85 | THRB (0.35) | TDP1ALDH1A1 | |
| SCHEMBL6846751 | 0.80 | MAPK1 (0.40) | TDP1ALDH1A1TP53 | |
| SCHEMBL4002907 | 0.76 | LMNA (0.33) | CYP3A4TDP1HSD17B10ALDH1A1 | |
| SCHEMBL1843328 | 0.74 | MAPT (0.33) | CYP3A4TDP1TAAR1HSD17B10ALDH1A1 | |
| SCHEMBL28438546 | 0.72 | PARP10 (0.39) | CYP3A4TDP1HSD17B10ALDH1A1TP53 | |
| SCHEMBL8101256 | 0.71 | TDP1 (0.32) | CYP3A4TDP1TAAR1HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11043882 | 0.70 | TDP1 (0.31) | CYP3A4TDP1TAAR1HSD17B10ALDH1A1 | |
| SCHEMBL29032762 | 0.70 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL8858302 | 0.69 | — | — | |
| SCHEMBL29007685 | 0.68 | HDAC4 (0.32) | TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | claimed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | claimed |