Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594745 | 0.92 | ALDH1A1 (0.52) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL28707190 | 0.90 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| Phenanthrene SCHEMBL27811748 | 0.83 | IDO1 (0.67) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL51777 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL2380017 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL28569068 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL29769915 | 0.80 | HPRT1 (0.78) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL593261 | 0.80 | HPRT1 (0.78) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL29445992 | 0.80 | HPRT1 (0.78) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL15551758 | 0.79 | PTPN1 (0.45) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6031098-A | Detection and treatment of duplex polynucleotide damage | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2000-02-29 | — | — | US | claimed |
| US-9969858-B2 | Metalloinsertor conjugates | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-05-15 | — | — | US | disclosed |
| US-20160222043-A1 | METALLOINSERTOR CONJUGATES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2016-08-04 | — | — | US | disclosed |
| US-9051345-B2 | Metalloinsertor complexes targeted to DNA mismatches | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2015-06-09 | — | — | US | disclosed |
| WO-2014200497-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-12-18 | — | — | WO | disclosed |
| US-8859533-B2 | Metalloinsertor complexes targeted to DNA mismatches | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2707377-A2 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | California Institute of Technology (US) | 2014-03-19 | — | — | EP | disclosed |
| US-20130345189-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-12-26 | — | — | US | disclosed |
| US-20130090319-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2013-04-11 | — | — | US | disclosed |
| WO-2012155004-A2 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | CALIFORNIA INSITUTE OF TECHNOLOGY (US) | 2012-11-15 | — | — | WO | disclosed |
| US-6777405-B2 | Detection and treatment of duplex polynucleotide damage | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2004-08-17 | — | — | US | disclosed |
| US-20030018020-A1 | Detection and treatment of duplex polynucleotide damage | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-01-23 | — | — | US | disclosed |
| US-6444661-B1 | DETECTING BASE PAIR MISMATCHES; HINDERED COMPOUNDS INTERCALATE BETWEEN BASES BUT ONLY WHERE NOT FULLY COMPLEMENTARY; RHODIUM WITH LIGANDS, BIDENTATE 5,6-CHRYSENE QUINONE DIIMINE; 2,2'-BIPYRIDYL; 1,10-PHENANTHROLINE | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-09-03 | — | — | US | disclosed |
| US-6306601-B1 | CONTACTING DUPLEX POLYNUCLEOTIDE WITH DETECTABLE HINDERED INTERCALATING COMPOUND WHICH CAN ONLY INSERT AT DAMAGE OR ERROR, THEN DETECTING INTERCALATION | THE CALIFORNIA INSTITUTE OF TECHNOLOGY | 2001-10-23 | — | — | US | disclosed |
| US-6031098-A | Detection and treatment of duplex polynucleotide damage | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2000-02-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222043-A1 | METALLOINSERTOR CONJUGATES | MSH2, MSH6, LIG1 | ALDH1A1 209/4885CYP1A2 3482/4885CYP2C9 3127/4885 |
| US-20130090319-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | MSH2, MSH6, PMS2 | ALDH1A1 2639/4885CYP1A2 4330/4885CYP2C9 3547/4885 |
| US-20030018020-A1 | Detection and treatment of duplex polynucleotide damage | POLH, POLN, POLR2H | ALDH1A1 2976/4885CYP1A2 2049/4885CYP2C9 2576/4885 |
| US-20130345189-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | MSH2, MSH6, PMS2 | ALDH1A1 2639/4885CYP1A2 4330/4885CYP2C9 3547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.