Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 2/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190298 | 0.87 | L3MBTL1 (0.36) | GPR119BCHEABCB1MEN1KMT2A | |
| SCHEMBL982157 | 0.85 | BCHE (0.36) | GPR119BCHEABCB1MEN1KMT2A | |
| SCHEMBL28125734 | 0.84 | KLK7 (0.36) | GPR119BCHEMEN1KMT2ABUB1 | |
| SCHEMBL14213914 | 0.84 | GPR119 (0.35) | GPR119BCHEABCB1MEN1KMT2A | |
| SCHEMBL18133541 | 0.83 | BUB1 (0.35) | GPR119BCHEABCB1MEN1KMT2A | |
| SCHEMBL14966067 | 0.79 | APLNR (0.41) | GPR119BCHEMEN1KMT2ABUB1 | |
| SCHEMBL7528678 | 0.77 | ESR2 (0.40) | GPR119BCHEMEN1KMT2ABUB1 | |
| SCHEMBL11911366 | 0.77 | GPR119 (0.39) | GPR119BCHEMEN1KMT2ABUB1 | |
| SCHEMBL12593934 | 0.76 | NR1H2 (0.41) | GPR119BCHEMEN1KMT2ABUB1 | |
| SCHEMBL1018306 | 0.76 | BCHE (0.38) | GPR119BCHEMEN1KMT2ABUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849019-A | A kind of azepine Cydic amide derivatives and preparation method thereof and purposes in medicine | 四川海思科制药有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-104470934-B | Kinases inhibitor | 爱仕达生物技术有限责任公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-105924379-A | Preparation method of 1-BOC-3-hydroxymethyl pyrrolidine | 苏州艾缇克药物化学有限公司 | 2016-09-07 | — | — | CN | disclosed |
| CN-104470934-A | Protein kinase inhibitors | ASTAR BIOTECH LLC | 2015-03-25 | — | — | CN | disclosed |
| US-20080119419-A1 | Bifunctional heterocyclic compounds and methods of making and using same | BioVersys AG (CH) | 2008-05-22 | — | — | US | disclosed |
| US-7335753-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-20070072811-A1 | Bifunctional heterocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. | 2007-03-29 | — | — | US | disclosed |
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119419-A1 | Bifunctional heterocyclic compounds and methods of making and using same | PCNA, DCX, ATIC | GPR119 1553/4885BCHE 923/4885PPARG 1410/4885 |
| US-20070072811-A1 | Bifunctional heterocyclic compounds and methods of making and using the same | PCNA, DCX, HPGDS | GPR119 1574/4885BCHE 911/4885PPARG 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.