Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2878868 | 1.00 | — | — | |
| SCHEMBL7987317 | 0.89 | KCNH2 (0.39) | — | |
| Oxalic Acid SCHEMBL7976828 | 0.76 | HRH3 (0.36) | — | |
| SCHEMBL650642 | 0.75 | HRH3 (0.46) | — | |
| SCHEMBL7987181 | 0.75 | GAA (0.55) | — | |
| SCHEMBL4376187 | 0.75 | L3MBTL1 (0.59) | — | |
| Oxalic Acid SCHEMBL7990912 | 0.74 | MEN1 (0.47) | — | |
| SCHEMBL4384169 | 0.74 | ALDH1A1 (0.48) | — | |
| SCHEMBL7991232 | 0.74 | HRH4 (0.66) | — | |
| SCHEMBL4378564 | 0.74 | HRH4 (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416046-A1 | USE OF HISTAMINE RECEPTOR H3 GENE IN CONTROLLING BODY WEIGHT OR FOOD INTAKE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-05-06 | — | — | EP | claimed |
| EP-1416046-A1 | USE OF HISTAMINE RECEPTOR H3 GENE IN CONTROLLING BODY WEIGHT OR FOOD INTAKE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-05-06 | — | — | EP | disclosed |