Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863068 | 0.86 | ADORA2A (0.61) | MEN1KMT2APOLBCNR1NPC1 | |
| SCHEMBL6869803 | 0.86 | ADORA2A (0.41) | MEN1KMT2APOLBKDRPDGFRB | |
| SCHEMBL6868095 | 0.84 | KDM4E (0.53) | MEN1KMT2ACNR1NPC1SMN1; SMN2 | |
| SCHEMBL6871448 | 0.82 | ADORA2A (0.65) | ADORA2A | |
| SCHEMBL6869707 | 0.82 | KIT (0.44) | MEN1KMT2APOLBCNR1NPC1 | |
| SCHEMBL6863092 | 0.82 | ADORA2A (0.64) | MEN1KMT2AADORA2A | |
| SCHEMBL6873157 | 0.81 | HPGDS (0.51) | KDRAKT1MAP4K4CHEK2CDK1 | |
| SCHEMBL6870493 | 0.81 | ADORA2A (0.40) | MEN1KMT2APOLBNPC1SMN1; SMN2 | |
| SCHEMBL6866973 | 0.78 | BACE1 (0.48) | KMT2APOLBNPC1SMN1; SMN2CAMK2D | |
| SCHEMBL6871382 | 0.77 | ADORA2A (0.59) | MEN1KMT2ANPC1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |