Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732202 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1CA2LMNA | |
| SCHEMBL30772132 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1CA2LMNA | |
| Water SCHEMBL9956053 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1CA2KDM4E | |
| SCHEMBL22367879 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1CA2LMNA | |
| SCHEMBL6256646 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1CA2LMNA | |
| SCHEMBL7449086 | 0.76 | TSHR (0.37) | ALDH1A1TSHRTDP1CA2MAPT | |
| SCHEMBL27669481 | 0.76 | ALDH1A1 (0.44) | ALDH1A1TSHRTDP1CA2POLB | |
| SCHEMBL5983424 | 0.73 | ALDH1A1 (0.36) | ALDH1A1TSHRTDP1CA2MEN1 | |
| Tromethamine SCHEMBL6571798 | 0.72 | ALDH1A1 (0.52) | ALDH1A1TSHRTDP1CA2MEN1 | |
| Tromethamine SCHEMBL8351464 | 0.71 | RXRA (0.40) | ALDH1A1TSHRTDP1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800416-B2 | MIXTURE OF FLUOROPOLYMER, PHOTOACTIVE MATERIAL AND CROSSLINKING AGENT | CLARIANT FINANCE (BVI) LTD. (VG) | 2004-10-05 | — | — | US | claimed |