SCHEMBL687632

SCHEMBL687632

CO[Si](CCCc1cccc2s[c]nc12)(OC)OC

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 7/20 0.32
MTNR1B P49286 7/20 0.32
ALOX5 P09917 1/20 0.31
PTGS2 P35354 1/20 0.31
PPARA Q07869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL558657 0.75 MEN1 (0.38)
SCHEMBL1639308 0.74 MTNR1A (0.40) MTNR1AMTNR1BALOX5PTGS2
SCHEMBL1639192 0.73 PTGS2 (0.38) MTNR1AMTNR1BALOX5PTGS2PPARA
SCHEMBL11324676 0.72 PTGS2 (0.39) MTNR1AMTNR1BPTGS2
SCHEMBL5006019 0.72 PNMT (0.35)
SCHEMBL558137 0.72 ALDH1A1 (0.49)
SCHEMBL329562 0.70 PTGS2 (0.38) MTNR1AMTNR1BPTGS2
Hydrogen Sulfide SCHEMBL28989708 0.69 SMN1; SMN2 (0.45) PTGS2
SCHEMBL1406060 0.68 AKR1B1 (0.47) MTNR1A
SCHEMBL16198395 0.67 ALDH1A1 (0.39) ALOX5PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3222440-B1 PNEUMATIC TIRE SUMITOMO RUBBER IND (JP) 2019-07-31 EP disclosed
EP-3222440-A1 PNEUMATIC TIRE Sumitomo Rubber Industries, Ltd. (JP) 2017-09-27 EP disclosed
EP-2993205-A1 PNEUMATIC TIRE, STUDLESS TIRE, METHOD FOR MANUFACTURING PNEUMATIC TIRE, AND METHOD FOR MANUFACTURING STUDLESS TIRE Sumitomo Rubber Industries, Ltd. (JP) 2016-03-09 EP disclosed
EP-2554553-A1 PROCESS FOR PRODUCTION OF MODIFIED CONJUGATED DIENE RUBBER, MODIFIED CONJUGATED DIENE RUBBER, AND RUBBER COMPOSITION JSR Corporation (JP) 2013-02-06 EP disclosed
EP-2157127-B1 RUBBER COMPOSITION FOR SIDEWALL AND PNEUMATIC TIRE MADE WITH THE SAME SUMITOMO RUBBER IND (JP) 2013-01-09 EP disclosed
EP-1829925-B1 RUBBER COMPOSITION, METHOD FOR PRODUCING SAME AND TIRE BRIDGESTONE CORP (JP) 2012-02-29 EP disclosed
EP-2157127-A1 RUBBER COMPOSITION FOR SIDEWALL AND PNEUMATIC TIRE MADE WITH THE SAME Sumitomo Rubber Industries, Ltd. (JP) 2010-02-24 EP disclosed
EP-1829925-A1 RUBBER COMPOSITION, METHOD FOR PRODUCING SAME AND TIRE Bridgestone Corporation (JP) 2007-09-05 EP disclosed
US-6656992-B2 Blend of natural rubber and synthetic diene-based rubbers, aluminum hydroxide particles, and carbon black or silica filler; tire treads, wear resistance BRIDGESTONE CORPORATION (JP) 2003-12-02 US disclosed
EP-1000965-B1 Rubber composition BRIDGESTONE CORP (JP) 2003-10-08 EP disclosed
US-20030149161-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2003-08-07 US disclosed
EP-1000965-A1 Rubber composition Bridgestone Corporation (JP) 2000-05-17 EP disclosed