Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 4/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822326 | 0.74 | NPY1R (0.43) | NPY1RNPY5RADRA1DADRA1AADRA1B | |
| SCHEMBL18869925 | 0.73 | NPY1R (0.41) | NPY1RNPY5RADRA1DADRA1AADRA1B | |
| SCHEMBL17333862 | 0.71 | LIPG (0.49) | NPY1RNPY5RADRA1DADRA1AADRA1B | |
| SCHEMBL12422869 | 0.71 | ADRA1D (0.58) | NPY1RNPY5RADRA1DADRA1AADRA1B | |
| SCHEMBL17928110 | 0.70 | NPY1R (0.41) | NPY1RNPY5RADRA1DADRA1AADRA1B | |
| SCHEMBL7476442 | 0.70 | ALDH1A1 (0.37) | ALOX15 | |
| SCHEMBL2750456 | 0.70 | THRB (0.51) | TSHRCYP19A1PREP | |
| SCHEMBL7104276 | 0.70 | NSD2 (0.55) | TP53TSHR | |
| SCHEMBL9688829 | 0.69 | DRD2 (0.63) | NPY1RNPY5RADRA1DADRA1AADRA1B | |
| SCHEMBL9688646 | 0.69 | DRD2 (0.63) | NPY1RNPY5RADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004505014-A | — | — | 2004-02-19 | — | — | JP | claimed |
| EP-1268463-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001077097-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-10-18 | — | — | WO | claimed |