Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.37 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886242 | 0.88 | HSP90AA1 (0.40) | ERCC1FEN1ERCC4RNASEH1PIN1 | |
| SCHEMBL6875745 | 0.83 | RIPK1 (0.42) | ERCC1FEN1ERCC4RNASEH1PIN1 | |
| SCHEMBL6883583 | 0.82 | ERCC1 (0.44) | ERCC1FEN1ERCC4PIN1KMT2A | |
| SCHEMBL6884733 | 0.81 | RAB9A (0.41) | ERCC1FEN1ERCC4RNASEH1PIN1 | |
| SCHEMBL6885172 | 0.81 | PIN1 (0.43) | ERCC1FEN1ERCC4PIN1 | |
| SCHEMBL6886352 | 0.80 | PIN1 (0.46) | ERCC1FEN1ERCC4PIN1 | |
| SCHEMBL6884260 | 0.80 | PIN1 (0.41) | ERCC1FEN1ERCC4RNASEH1PIN1 | |
| SCHEMBL6882031 | 0.79 | SLC6A4 (0.36) | ERCC1FEN1ERCC4KMT2AATM | |
| SCHEMBL6884280 | 0.79 | RNASEH1 (0.44) | ERCC1FEN1ERCC4RNASEH1PIN1 | |
| SCHEMBL6885455 | 0.78 | MEN1 (0.42) | ERCC1FEN1ERCC4PIN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004096128-A2 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-11 | — | — | WO | claimed |
| WO-2004096128-A2 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-11 | — | — | WO | disclosed |