Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13575374 | 0.79 | ALDH1A1 (0.41) | CYP2A6KDM4EATRL3MBTL1ALDH1A1 | |
| SCHEMBL14685050 | 0.78 | KDM4E (0.46) | CYP2A6KDM4ELMNACCR1CCR5 | |
| SCHEMBL11005639 | 0.76 | PRMT5 (0.45) | KDM4EPRMT5WDR77ATRL3MBTL1 | |
| SCHEMBL10843819 | 0.76 | MAPT (0.46) | ATRALDH1A1MAPTCYP2D6 | |
| SCHEMBL10845139 | 0.76 | MAPT (0.49) | ATRMAPTCYP2D6CYP19A1CYP2C9 | |
| SCHEMBL9231553 | 0.75 | CA12 (0.49) | CYP2A6KDM4ELMNAMETAP1PRMT5 | |
| SCHEMBL30989132 | 0.75 | KDM4E (0.72) | CYP2A6KDM4ELMNACCR1CCR5 | |
| SCHEMBL1566968 | 0.75 | KDM4E (0.72) | CYP2A6KDM4ELMNACCR1CCR5 | |
| SCHEMBL30989133 | 0.75 | KDM4E (0.72) | CYP2A6KDM4ELMNACCR1CCR5 | |
| SCHEMBL23480006 | 0.74 | KDM4E (0.52) | CYP2A6KDM4ELMNACCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118731225-A | Method for measuring content of pirenzepine intermediate | 海南葫芦娃药业集团股份有限公司 | 2024-10-01 | — | — | CN | claimed |
| EP-3768671-B1 | SUBSTITUTED IMIDAZOLIDIN-2-ONE DERIVATIVES AS PRMT5 INHIBITORS | AURIGENE ONCOLOGY LTD (IN) | 2024-05-22 | — | — | EP | claimed |
| CN-116930351-A | Method for measuring related substances of key starting materials of pirenzepine by HPLC | 上海现代制药股份有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-116396212-B | Preparation method of high-purity pirenzenenaphthalene intermediate | 天津辰欣药物研究有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-116396212-A | Preparation method of high-purity pirenzenenaphthalene intermediate | 天津辰欣药物研究有限公司 | 2023-07-07 | — | — | CN | claimed |
| US-11542275-B2 | Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2023-01-03 | — | — | US | claimed |
| CN-109799298-B | Detection method of related substances in Perampanel bulk drug | 南京海纳医药科技股份有限公司 | 2022-01-07 | — | — | CN | claimed |
| US-20190091156-A1 | MILRINONE CONTROLLED-RELEASE FORMULATION | Baker Heart and Diabetes Institute (AU) | 2019-03-28 | — | — | US | claimed |
| US-20170348292-A1 | METHOD OF TREATMENT | Baker Heart and Diabetes Institute (AU) | 2017-12-07 | — | — | US | claimed |
| EP-3236963-A1 | METHOD OF TREATMENT | Cardiora Pty Ltd (AU) | 2017-11-01 | — | — | EP | claimed |
| EP-2744496-A1 | CONTROLLED-RELEASE FORMULATION | Baker IDI Heart and Diabetes Institute Holdings Ltd (AU) | 2014-06-25 | — | — | EP | claimed |
| EP-2123639-B1 | PROCESS FOR PRODUCTION OF 2,3'-BIPYRIDYL-6'-ONE | FUJIFILM FINECHEMICALS CO LTD (JP) | 2014-03-26 | — | — | EP | claimed |
| WO-2013023250-A1 | CONTROLLED-RELEASE FORMULATION | BAKER IDI HEART & DIABETES INSTITUTE HOLDINGS LIMITED (AU) | 2013-02-21 | — | — | WO | claimed |
| US-20100016603-A1 | PRODUCTION PROCESS OF 2,3'-BIPYRIDYL-6'-ONE | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2010-01-21 | — | — | US | claimed |
| EP-2123639-A1 | PROCESS FOR PRODUCTION OF 2,3'-BIPYRIDYL-6'-ONE | Fujifilm Finechemicals Co. Ltd. (JP) | 2009-11-25 | — | — | EP | claimed |
| EP-1553086-B1 | PROCESS FOR PRODUCING 5-(2 '-PYRIDYL)-2-PYRIDONE DERIVATIVE | KURARAY CO (JP) | 2009-10-07 | — | — | EP | claimed |
| US-7524967-B2 | Process for producing 5-(2′-pyridyl)-2-pyridone derivative | KURARAY CO., LTD. (JP) | 2009-04-28 | — | — | US | claimed |
| US-20060004205-A1 | Process for producing 5-(2'-pyridyl)-2-pyridone derivative | KURARAY CO. LTD. (JP) | 2006-01-05 | — | — | US | claimed |
| EP-1553086-A1 | PROCESS FOR PRODUCING 5-(2 -PYRIDYL)-2-PYRIDONE DERIVATIVE | Kuraray Co., Ltd. (JP) | 2005-07-13 | — | — | EP | claimed |
| EP-0127756-A1 | Process for the preparation of 5-pyridyl-pyridine-2(1H)-ones | FABRICA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS ABELLO, S.A. (ES) | 1984-12-12 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190091156-A1 | MILRINONE CONTROLLED-RELEASE FORMULATION | SIRT5, TNNI3, PROC | CYP2A6 363/4885KDM4E 3421/4885LMNA 1121/4885 |
| US-11542275-B2 | Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors | PRMT5, PRMT1, PRMT8 | CYP2A6 4121/4885KDM4E 59/4885LMNA 3013/4885 |
| US-20100016603-A1 | PRODUCTION PROCESS OF 2,3'-BIPYRIDYL-6'-ONE | AMPD2, PARP12, MRPL21 | CYP2A6 284/4885KDM4E 992/4885LMNA 4248/4885 |
| US-20060004205-A1 | Process for producing 5-(2'-pyridyl)-2-pyridone derivative | PNPO, PDXK, CYP2B6 | CYP2A6 23/4885KDM4E 674/4885LMNA 3610/4885 |
| US-20170348292-A1 | METHOD OF TREATMENT | TNNI3, NPPA, TNNT2 | CYP2A6 1573/4885KDM4E 2704/4885LMNA 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.