Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688778 | 0.82 | CSNK2A1 (0.37) | TSHRPARP1GLAMAPTMEN1 | |
| SCHEMBL689128 | 0.82 | MAPT (0.37) | KDM4ESMN1; SMN2GAATSHRGLA | |
| SCHEMBL689301 | 0.81 | PTPRC (0.34) | SMN1; SMN2GAATSHRGLAMAPT | |
| SCHEMBL688883 | 0.81 | KEAP1 (0.38) | SMN1; SMN2GAATSHRPARP1GLA | |
| SCHEMBL11347462 | 0.80 | KEAP1 (0.41) | KDM4ESMN1; SMN2PLA2G10PARP1CA1 | |
| SCHEMBL4995900 | 0.76 | ALDH1A1 (0.47) | KDM4ESMN1; SMN2GAATSHRGLA | |
| SCHEMBL12328328 | 0.73 | KDM4E (0.50) | KDM4ESMN1; SMN2PARP1CA1CA2 | |
| SCHEMBL2835948 | 0.70 | PARP1 (0.55) | KDM4ESMN1; SMN2GAATSHRPLA2G10 | |
| SCHEMBL7016460 | 0.70 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2GAAPARP1CA1 | |
| SCHEMBL12329333 | 0.69 | KDM4E (0.47) | KDM4ESMN1; SMN2PARP1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |