Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | GART | P22102 | 1/20 | 0.38 |
| ▸ | ATIC | P31939 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887186 | 1.00 | CLPP (0.43) | CLPPALDH1A1GAAHPGDCTSK | |
| SCHEMBL9782307 | 0.84 | ALDH1A1 (0.52) | CLPPALDH1A1GAAHPGDCTSK | |
| SCHEMBL9782310 | 0.84 | ALDH1A1 (0.52) | CLPPALDH1A1GAAHPGDCTSK | |
| SCHEMBL6886320 | 0.83 | HDAC1 (0.44) | ALDH1A1HPGDKDRTAS1R3TAS1R1 | |
| SCHEMBL6886329 | 0.83 | HDAC1 (0.44) | ALDH1A1HPGDKDRTAS1R3TAS1R1 | |
| SCHEMBL8722807 | 0.80 | ITGA4 (0.43) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL9782611 | 0.80 | ITGA4 (0.43) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL8725881 | 0.78 | TYMS (0.45) | ALDH1A1KDRTAS1R3TAS1R1MAPK14 | |
| SCHEMBL8722803 | 0.78 | TYMS (0.38) | KDRTAS1R3TAS1R1MAPK14 | |
| SCHEMBL15618501 | 0.78 | CLPP (0.64) | CLPPALDH1A1MAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259878-A1 | Fluoromethotrexates and uses therefor | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2004-12-23 | — | — | US | disclosed |
| EP-0696270-B1 | 4-AMINO-FLUOROBENZAMIDES AND THEIR USE AS CYTOTOXIC PRODRUGS | CANCER RES CAMPAIGN TECH (GB) | 1998-11-04 | — | — | EP | disclosed |
| US-5811454-A | 3-FLUOROBENZAMIDES WITH NITROGEN MUSTARD GROUPS; ANTICARCINOGENIC AGENTS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259878-A1 | Fluoromethotrexates and uses therefor | MTX1, DHFR, SLC46A1 | CLPP 3260/4885ALDH1A1 1479/4885GAA 2957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.