Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895074 | 0.92 | HPGD (0.44) | ALDH1A1HPGDTDP1KDM4ELMNA | |
| SCHEMBL6890858 | 0.83 | SIGMAR1 (0.50) | ALDH1A1LMNAGAANPSR1 | |
| SCHEMBL6887458 | 0.82 | SIGMAR1 (0.51) | KMT2A | |
| SCHEMBL6887766 | 0.81 | ALDH1A1 (0.33) | ALDH1A1HPGDPOLBKDM4EKMT2A | |
| SCHEMBL6894568 | 0.80 | CYP3A4 (0.44) | ALDH1A1KDM4ELMNAKMT2ASMN1; SMN2 | |
| SCHEMBL6890899 | 0.80 | AOC3 (0.36) | ALDH1A1KDM4ELMNAKMT2ASMN1; SMN2 | |
| SCHEMBL6889436 | 0.78 | SIGMAR1 (0.49) | ALDH1A1POLBLMNASMN1; SMN2ANPEP | |
| SCHEMBL6891363 | 0.76 | KMT2A (0.55) | ALDH1A1TDP1KDM4EKMT2AGAA | |
| SCHEMBL6895263 | 0.76 | KDM4E (0.43) | ALDH1A1KDM4ELMNAANPEPADRA2A | |
| SCHEMBL6894924 | 0.76 | KDM4E (0.43) | ALDH1A1KDM4ELMNAANPEPADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |