SCHEMBL6894755

SCHEMBL6894755

CCc1ccccc1C(N)=S

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
GABRA1 P14867 2/20 0.43
GABRB2 P47870 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
CLCN2 P51788 1/20 0.40
PKM P14618 1/20 0.39
KMT2A Q03164 2/20 0.39
GRIN2D O15399 1/20 0.39
GRIN3B O60391 1/20 0.39
GRIN1 Q05586 1/20 0.39
GRIN2A Q12879 1/20 0.39
GRIN2B Q13224 1/20 0.39
GRIN2C Q14957 1/20 0.39
GRIN3A Q8TCU5 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
PARP1 P09874 1/20 0.39
TSHR P16473 1/20 0.38
F2R P25116 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6894654 0.83 PKM (0.44) GAAALDH1A1MAPTPKM
SCHEMBL7896315 0.83 KMT2A (0.42) GAAALDH1A1MAPTSMN1; SMN2PKM
SCHEMBL19468334 0.82 GABRA1 (0.43) GAAALDH1A1MAPTGABRA1GABRB2
SCHEMBL4768903 0.80 LIPG (0.44) MAPTKMT2ATSHR
SCHEMBL6575706 0.80 GABRA1 (0.44) GAAALDH1A1MAPTGABRA1GABRB2
SCHEMBL162322 0.80 MAPT (0.52) GAAALDH1A1MAPTGABRA1GABRB2
SCHEMBL6555382 0.80 MAPT (0.52) GAAALDH1A1MAPTGABRA1GABRB2
SCHEMBL27783600 0.79 ALDH1A1 (0.50) GAAALDH1A1MAPTGABRA1GABRB2
SCHEMBL14696823 0.79 PKM (0.41) GAAALDH1A1MAPTPKMKMT2A
SCHEMBL2081561 0.79 LIPG (0.51) MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113816882-B Method for preparing 2-alkyl thiobenzonitrile 常州大学 2022-07-19 CN disclosed
CN-113816882-A Method for preparing 2-alkyl thiobenzonitrile 常州大学 2021-12-21 CN disclosed
EP-1126833-A4 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES INC (US) 2004-09-08 EP disclosed
EP-1126833-A2 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2001-08-29 EP disclosed
US-6277998-B1 REACTING 2-CYANO-4-OXO-4H-BENZOPYRAN COMPOUND WITH HYDROGEN SULFIDE AND THEN REACTING PROUDCT WITH ALKYL HALIDE; REACTING THE PRODUCT WITH HYDRAZINE OR ITS SALT AND THEN WITH NITROUS ACID COMPOUND TO OBTAIN TETRAZOLE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-21 US disclosed
US-6191289-B1 REACTING A 4-OXO-4H-BENZOPYRAN GROUP SUBSTITUTED WITH AMIDE OR A PHENYL GROUP IN ITS 2 POSITION IS REACTED WITH ANHYDROUS HYDRAZINE OR SALT IN PRESENCE OF CATALYST FOLLOWED BY REACTING WITH NITROUS ACID OR SALT TO FORM TETRAZOLE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-02-20 US disclosed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO disclosed
US-5874593-A SULFUR CONTAINING AMIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-02-23 US disclosed
EP-0711762-A1 PROCESS FOR PRODUCING TETRAZOLE COMPOUND AND INTERMEDIATE THEREFOR SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-05-15 EP disclosed
US-4008264-A Process for the preparation of aromatic thiocarboxylic acid amides HOECHST AKTIENGESELLSCHAFT (DT) 1977-02-15 US disclosed