Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462975 | 0.90 | TRPM8 (0.47) | PTGS2TRPM8KDM4EALDH1A1HPGD | |
| SCHEMBL7462498 | 0.88 | PTGS2 (0.58) | PTGS2TRPM8KDM4EALDH1A1NPC1 | |
| SCHEMBL7457268 | 0.88 | ALDH1A1 (0.52) | TRPM8KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL27428321 | 0.86 | PTGS2 (0.43) | PTGS2TRPM8KDM4EALDH1A1NPC1 | |
| SCHEMBL7459503 | 0.81 | PTGDR2 (0.43) | PTGDR2 | |
| SCHEMBL7458932 | 0.78 | TRPM8 (0.47) | PTGS2TRPM8KDM4EALDH1A1HPGD | |
| SCHEMBL7457281 | 0.76 | ALDH1A1 (0.52) | TRPM8KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7462671 | 0.75 | L3MBTL1 (0.46) | TRPM8KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL6598899 | 0.75 | PTGDR2 (0.43) | PTGDR2 | |
| SCHEMBL1249510 | 0.75 | ALDH1A1 (0.52) | TRPM8KDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806275-B2 | PSYCHOLOGICAL DISORDERS; SIDE EFFECT REDUCTION | NIHON NOHYAKU CO., LTD. (JP) | 2004-10-19 | — | — | US | disclosed |
| EP-0940401-B1 | 2-CARBONYLTHIAZOLE DERIVATIVES AND USE OF THE SAME | TAISHO PHARMACEUTICAL CO LTD (JP) | 2002-11-06 | — | — | EP | disclosed |
| US-20020156283-A1 | Arylpiperidine derivatives and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 2002-10-24 | — | — | US | disclosed |
| CN-1088707-C | 2-carbonylthiazole derivatives and use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2002-08-07 | — | — | CN | disclosed |
| US-6407121-B1 | DOPAMINE D4 RECEPTOR ANTAGONISTS; PSYCHOLOGICAL AND BRAIN DISORDERS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | NIHON NOHYAKU CO., LTD. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1070715-A1 | ARYLPIPERIDINE DERIVATIVES AND USE THEREOF | Nihon Nohyaku Co., Ltd. (JP) | 2001-01-24 | — | — | EP | disclosed |
| US-6166033-A | 2-carbonylthiazole derivatives and use of the same | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| CN-1237971-A | 2-carbonylthiazole derivatives and use of the same | TAISHO PHARMACEUTICAL CO LTD (JP) | 1999-12-08 | — | — | CN | disclosed |
| EP-0940401-A1 | 2-CARBONYLTHIAZOLE DERIVATIVES AND USE OF THE SAME | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1999-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156283-A1 | Arylpiperidine derivatives and use thereof | DRD1, DRD4, DRD2 | PTGS2 2880/4885TRPM8 2892/4885KDM4E 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.