Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.57 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.47 |
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138155 | 0.99 | MAPT (0.58) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL11431835 | 0.85 | MEN1 (0.53) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL11226201 | 0.81 | HSD17B10 (0.49) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| Sulfuric Acid SCHEMBL11263163 | 0.80 | MEN1 (0.58) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| Lactic Acid SCHEMBL11262321 | 0.78 | KDM4E (0.66) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL1228387 | 0.77 | MEN1 (0.58) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL8355586 | 0.75 | KDM4E (0.43) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL11608363 | 0.75 | MEN1 (0.63) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL11147039 | 0.75 | MEN1 (0.57) | MAPTMEN1KMT2AKDM4EHSD17B10 | |
| Ethacridine SCHEMBL29355684 | 0.74 | MEN1 (0.98) | MAPTMEN1KMT2AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731336-A | Immunoassay for complement fragments | AMERSHAM INTERNATIONAL PLC (GB) | 1988-03-15 | — | — | US | claimed |
| EP-0097440-A1 | Method and kit for removing and assaying complement system fragments | THE UPJOHN COMPANY (US) | 1984-01-04 | — | — | EP | claimed |
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | WASHINGTON UNIVERSITY (US) | 2025-03-11 | — | — | US | disclosed |
| US-11896589-B2 | Diazinyl amino acridines and medical uses thereof | MYCURAL THERAPEUTICS AB (SE) | 2024-02-13 | — | — | US | disclosed |
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | WASHINGTON UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| CN-112955009-B | Composition, sprayer and wiping cloth | 富士胶片株式会社 | 2022-10-25 | — | — | CN | disclosed |
| US-20210228754-A1 | COMPOSITION, SPRAY, AND WIPER | FUJIFILM CORPORATION (JP) | 2021-07-29 | — | — | US | disclosed |
| CN-112955135-A | Composition, sprayer and wiping cloth | 富士胶片株式会社 | 2021-06-11 | — | — | CN | disclosed |
| CN-112955009-A | Composition, sprayer and wiping cloth | 富士胶片株式会社 | 2021-06-11 | — | — | CN | disclosed |
| US-20200405707-A1 | DIAZINYL AMINO ACRIDINES AND MEDICAL USES THEREOF | MYCURAL THERAPEUTICS AB (SE) | 2020-12-31 | — | — | US | disclosed |
| EP-3743409-A1 | DIAZINYL AMINO ACRIDINES AND MEDICAL USES THEREOF | Larsson, Lars-Gunnar Olof (SE) | 2020-12-02 | — | — | EP | disclosed |
| WO-2000025787-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000025787-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| US-5719189-A | CONTAINING TRIPHENYLMETHANE | TETRA WERKE DR. RER. NAT. U. BAENSCH GMBH (DE) | 1998-02-17 | — | — | US | disclosed |
| US-5712290-A | QUINOLINE DERIVATIVES | TETRA WERKE DR. RER. NAT. U. BAENSCH GMBH (DE) | 1998-01-27 | — | — | US | disclosed |
| US-5670513-A | Medicinal feed for the systemic treatment of ectoparasitic and ectobacterial diseases of fish | TETRA WERKE DR. RER. NAT. U. BAENSCH GMBH (DE) | 1997-09-23 | — | — | US | disclosed |
| US-5618847-A | MALACHITE GREEN | TETRA WERKE DR. RER. NAT. U. BAENSCH GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0097440-B1 | METHOD AND KIT FOR REMOVING AND ASSAYING COMPLEMENT SYSTEM FRAGMENTS | THE UPJOHN COMPANY (US) | 1986-09-24 | — | — | EP | disclosed |
| US-4286063-A | CONTROLLING THE MOLECULAR WEIGHT OF UROKINASE BY ADJUSTING THE PH | THE GREEN CROSS CORPORATION (JP) | 1981-08-25 | — | — | US | disclosed |
| US-4000121-A | PRODUCTION OF ANTISERA COMPRISING FRACTIONATING PLASMA OR SERUM WITH AN ETHYLENE OXIDE-POLYOXYPROPYLENE BLOCK COPOLYMER | BAXTER TRAVENOL LABORATORIES, INC. (US) | 1976-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | NADK, NAPRT, TIPARP | MEN1 3678/4885THRB 917/4885DHFR 871/4885 |
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | NADK, NAPRT, TIPARP | MEN1 3678/4885THRB 917/4885DHFR 871/4885 |
| US-11896589-B2 | Diazinyl amino acridines and medical uses thereof | MYC, MYCBP, MEN1 | MEN1 3/4885THRB 1732/4885DHFR 210/4885 |
| US-20200405707-A1 | DIAZINYL AMINO ACRIDINES AND MEDICAL USES THEREOF | MYC, MYCBP, MEN1 | MEN1 3/4885THRB 1732/4885DHFR 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.