Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.44 |
| ▸ | NQO2 | P16083 | 3/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | AREG | P15514 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127952 | 0.77 | SIGMAR1 (0.47) | OPRM1 | |
| SCHEMBL6920302 | 0.74 | HDAC8 (0.53) | OPRM1MMP1MMP9MMP3ADAM17 | |
| SCHEMBL6920539 | 0.74 | HTR1A (0.50) | OPRM1TNFNOD2NOD1MMP1 | |
| SCHEMBL6919911 | 0.73 | OPRM1 (0.47) | OPRM1OPRD1OPRK1NR1D1 | |
| SCHEMBL6820388 | 0.71 | HDAC8 (0.48) | MMP1MMP9MMP3AREGADAM17 | |
| SCHEMBL17231980 | 0.69 | PPARD (0.47) | TNFNOD2NOD1HDAC8DRD2 | |
| SCHEMBL29538605 | 0.68 | HDAC8 (0.49) | HDAC8OPRK1DRD4 | |
| SCHEMBL506516 | 0.68 | HDAC3 (0.60) | — | |
| SCHEMBL4825496 | 0.68 | SIGMAR1 (0.50) | OPRM1OPRD1OPRK1 | |
| SCHEMBL32676928 | 0.67 | NAMPT (0.47) | OPRM1MMP3OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041816-A1 | AZACYCLIC COMPOUNDS AS OREXIN RECEPTOR ANTAGONIST | GLAXO GROUP LIMITED (GB) | 2004-05-21 | — | — | WO | disclosed |