Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921074 | 0.86 | TBXAS1 (0.48) | ADORA2AADORA1KDM4EHSD17B10NPC1 | |
| SCHEMBL6918809 | 0.84 | F2 (0.46) | F2F12KDM4EHSD17B10NPC1 | |
| SCHEMBL6920919 | 0.84 | TBXAS1 (0.52) | F2KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL6921278 | 0.80 | TSHR (0.46) | KDM4EHSD17B10HTTMAPTHPGD | |
| SCHEMBL6922174 | 0.79 | MAPT (0.43) | KDM4EHSD17B10NPC1RAB9AHTT | |
| SCHEMBL6919541 | 0.77 | HTT (0.41) | KDM4EHSD17B10HTTMAPTHPGD | |
| SCHEMBL6922335 | 0.77 | MAPT (0.41) | KDM4EHSD17B10NPC1RAB9AHTT | |
| SCHEMBL6918790 | 0.77 | LMNA (0.42) | KDM4EHSD17B10NPC1RAB9AHTT | |
| SCHEMBL6919643 | 0.76 | L3MBTL1 (0.46) | HSD17B10NPC1RAB9ATBXAS1HTT | |
| SCHEMBL6919131 | 0.75 | ALDH1A1 (0.40) | KDM4EHSD17B10NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |