Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of P-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 known ✓ | P29475 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 2/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL28275748 | 0.96 | MAPK1 (0.57) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL28761845 | 0.93 | MAPK1 (0.63) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL27975093 | 0.91 | MAPK1 (0.61) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL309332 | 0.91 | TDP1 (0.61) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL14125735 | 0.91 | TDP1 (0.61) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| Acetic Acid SCHEMBL27877969 | 0.91 | MAPK1 (0.71) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL27462973 | 0.91 | TDP1 (0.60) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL8678506 | 0.91 | MAPK1 (0.52) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL17289474 | 0.89 | TDP1 (0.59) | MAPK1TDP1ALDH1A1MEN1KMT2A | |
| P-Nitrophenol SCHEMBL15203620 | 0.89 | ALDH1A1 (0.64) | MAPK1TDP1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 585 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120158494-A | Quality detection and analysis method for fen-flavor Daqu | 山西杏花村汾酒厂股份有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-119552943-A | Daqu variety identification method | 山西杏花村汾酒厂股份有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-107189955-B | Novel deep-sea thermostable alkaline esterase and application thereof | 自然资源部第二海洋研究所 | 2022-07-15 | — | — | CN | claimed |
| CN-113444711-A | Preparation method of peptide assembled hydrolytic enzyme with substrate selectivity | 天津大学 | 2021-09-28 | — | — | CN | claimed |
| CN-109971734-B | PH-insensitive high-temperature-tolerant HSL family lipid hydrolase and application thereof | 杭州浦泰生物科技有限公司 | 2021-04-13 | — | — | CN | claimed |
| CN-109943550-B | Marine bacterium-derived esterase Erp3, and coding gene and application thereof | 自然资源部第二海洋研究所 | 2021-01-26 | — | — | CN | claimed |
| CN-108504618-B | Recombinant bacterium for expressing lipase with R configuration selectivity and application thereof | 华南理工大学 | 2020-08-18 | — | — | CN | claimed |
| CN-108285895-B | Esterase EstC11, and coding gene and application thereof | 中国科学院南海海洋研究所 | 2020-06-23 | — | — | CN | claimed |
| CN-111153798-A | Chiral gamma-hydroxybutyric acid derivative and preparation method thereof | 浙江工业大学 | 2020-05-15 | — | — | CN | claimed |
| CN-107893060-B | Thermostable salt-tolerant SGNH family hydrolase derived from marine bacteria and application thereof | 自然资源部第二海洋研究所 | 2020-05-05 | — | — | CN | claimed |
| US-20030224028-A1 | Metal complexes for promoting skin desquamation and/or stimulating epidermal renewal | SOCIETE L'OREAL S.A. (FR) | 2003-12-04 | — | — | US | claimed |
| EP-4731607-A1 | PIPERIDINE, PYRROLIDINE AND ISOINDOLE PRECURSORS OF PROBES FOR OXIDATIVE STRESS | Centre National de la Recherche Scientifique (FR) | 2026-04-29 | — | — | EP | disclosed |
| US-12559735-B2 | Device for detecting organophosphates | PLANTVAX, INC. (US) | 2026-02-24 | — | — | US | disclosed |
| EP-4587163-A1 | METHOD OF SEQUESTERING ATMOSPHERIC CARBON | Fabricnano Limited (GB) | 2025-07-23 | — | — | EP | disclosed |
| CN-120158494-A | Quality detection and analysis method for fen-flavor Daqu | 山西杏花村汾酒厂股份有限公司 | 2025-06-17 | — | — | CN | disclosed |
| US-5110833-A | Preparation of synthetic enzymes and synthetic antibodies and use of the thus prepared enzymes and antibodies | MOSBACH KLAUS (SE) | 1992-05-05 | — | — | US | disclosed |
| EP-0462206-A1 | EXPANDED PORPHYRINS: LARGE PORPHYRIN-LIKE TRIPYRROLEDIMETHINE-DERIVED MACROCYCLES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-12-27 | — | — | EP | disclosed |
| US-5043347-A | Indanes and analgesic compositions and methods thereof | ROUSSEL UCLAF (FR) | 1991-08-27 | — | — | US | disclosed |
| WO-1990010633-A1 | EXPANDED PORPHYRINS: LARGE PORPHYRIN-LIKE TRIPYRROLEDIMETHINE-DERIVED MACROCYCLES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1990-09-20 | — | — | WO | disclosed |
| US-4935498-A | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1990-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12559735-B2 | Device for detecting organophosphates | BCHE, LIPE, ACHE | NOS1 2657/4885MAPK1 4457/4885TDP1 920/4885 |
| US-20030224028-A1 | Metal complexes for promoting skin desquamation and/or stimulating epidermal renewal | MC1R, LGMN, CUTA | NOS1 394/4885MAPK1 1712/4885TDP1 4438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.