Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920933 | 0.77 | PARP1 (0.44) | ALDH1A1GPR84GSK3BPARP1 | |
| SCHEMBL4356446 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MAPK1GPR84GSK3BPARP1 | |
| SCHEMBL6919860 | 0.75 | PARP1 (0.38) | ALDH1A1MAPK1GPR84GSK3BPARP1 | |
| SCHEMBL9083256 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MAPK1GPR84GSK3BPARP1 | |
| SCHEMBL8435741 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MAPK1GPR84GSK3BPARP1 | |
| SCHEMBL225 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MAPK1GPR84GSK3BPARP1 | |
| SCHEMBL6922119 | 0.74 | MAPT (0.36) | ALDH1A1MAPTLMNA | |
| SCHEMBL7716174 | 0.72 | GPR84 (0.35) | ALDH1A1MAPK1GPR84GSK3BPARP1 | |
| SCHEMBL9081675 | 0.71 | GPR84 (0.45) | ALDH1A1MAPK1GPR84PI4KAPI4K2B | |
| SCHEMBL8823569 | 0.71 | ALDH1A1 (0.40) | ALDH1A1MAPK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074258-A1 | NOVEL SULPHATED IMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF, NOVEL INTERMEDIATES OBTAINED, APPLICATION THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ABOVE | CAILLE JEAN-CLAUDE (FR) | 2004-09-02 | — | — | WO | disclosed |
| EP-0465368-B1 | Sulfur derivatives of imidazole, process for their preparation, intermediates, their use as medicaments, and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-20 | — | — | EP | disclosed |
| US-5684028-A | ANGIOTENSIN II INHIBITORS | ROUSSEL UCLAF (FR) | 1997-11-04 | — | — | US | disclosed |
| US-5599830-A | ANGIOTENSIN INHIBITORS | ROUSSEL UCLAF (FR) | 1997-02-04 | — | — | US | disclosed |
| US-5412101-A | Angiotensin II inhibitor | ROUSSEL-UCLAF (FR) | 1995-05-02 | — | — | US | disclosed |
| EP-0465368-A1 | Sulfur derivatives of imidazole, process for their preparation, intermediates, their use as medicaments, and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1992-01-08 | — | — | EP | disclosed |