Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919672 | 0.80 | PARP1 (0.46) | PARP1GSK3BGPR84HDAC6ALDH1A1 | |
| SCHEMBL6922379 | 0.77 | ALDH1A1 (0.38) | PARP1GSK3BGPR84ALDH1A1 | |
| SCHEMBL8823589 | 0.75 | TUBB4A (0.50) | PARP1ALDH1A1 | |
| SCHEMBL6920932 | 0.73 | ALDH1A1 (0.33) | DHFRHDAC6ALDH1A1 | |
| SCHEMBL6922390 | 0.70 | AGTR1 (0.39) | ALDH1A1 | |
| SCHEMBL4356446 | 0.70 | ALDH1A1 (0.42) | PARP1GSK3BGPR84ALDH1A1 | |
| SCHEMBL9512926 | 0.68 | HPGD (0.41) | PARP1 | |
| SCHEMBL9083256 | 0.68 | ALDH1A1 (0.41) | PARP1GSK3BGPR84ALDH1A1 | |
| SCHEMBL225 | 0.68 | ALDH1A1 (0.41) | PARP1GSK3BGPR84ALDH1A1 | |
| SCHEMBL8435741 | 0.68 | ALDH1A1 (0.41) | PARP1GSK3BGPR84ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074258-A1 | NOVEL SULPHATED IMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF, NOVEL INTERMEDIATES OBTAINED, APPLICATION THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ABOVE | CAILLE JEAN-CLAUDE (FR) | 2004-09-02 | — | — | WO | disclosed |
| EP-0465368-B1 | Sulfur derivatives of imidazole, process for their preparation, intermediates, their use as medicaments, and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-20 | — | — | EP | disclosed |
| US-5684028-A | ANGIOTENSIN II INHIBITORS | ROUSSEL UCLAF (FR) | 1997-11-04 | — | — | US | disclosed |
| US-5599830-A | ANGIOTENSIN INHIBITORS | ROUSSEL UCLAF (FR) | 1997-02-04 | — | — | US | disclosed |
| US-5412101-A | Angiotensin II inhibitor | ROUSSEL-UCLAF (FR) | 1995-05-02 | — | — | US | disclosed |
| EP-0465368-A1 | Sulfur derivatives of imidazole, process for their preparation, intermediates, their use as medicaments, and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1992-01-08 | — | — | EP | disclosed |