Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 7/20 | 0.55 |
| ▸ | CTSS | P25774 | 7/20 | 0.55 |
| ▸ | CTSB | P07858 | 4/20 | 0.55 |
| ▸ | CTSV | O60911 | 3/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 3/20 | 0.41 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928739 | 0.86 | CTSL (0.58) | CTSLCTSSCTSBCTSVGPR132 | |
| SCHEMBL7466927 | 0.83 | CTSL (0.48) | CTSLCTSSCTSBCTSKKMT2A | |
| SCHEMBL6929121 | 0.82 | CTSS (0.52) | CTSLCTSSCTSBCTSVKMT2A | |
| SCHEMBL6926223 | 0.81 | CTSS (0.51) | CTSLCTSSCTSBCTSVKMT2A | |
| SCHEMBL7464381 | 0.81 | CTSL (0.47) | CTSLCTSSCTSBCTSVROCK2 | |
| SCHEMBL7463738 | 0.76 | TAS1R3 (0.45) | CTSLCTSSCTSBCTSKKMT2A | |
| SCHEMBL6928352 | 0.74 | CTSL (0.44) | CTSLCTSSCTSBCTSVCTSK | |
| SCHEMBL6923642 | 0.74 | CTSL (0.47) | CTSLCTSSCTSBCTSKF2 | |
| SCHEMBL6927425 | 0.74 | CTSL (0.55) | CTSLCTSSCTSBCTSVCTSK | |
| SCHEMBL7462366 | 0.73 | CTSS (0.53) | CTSLCTSSCTSBCTSVCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | claimed |
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |