Pyromellitic Acid

Pyromellitic Acid

SCHEMBL692530

O.O=C(O)c1cc(C(=O)O)c(C(=O)O)cc1C(=O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Pyromellitic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 known ✓ P35354 2/20 0.43
ALOX5 known ✓ P09917 1/20 0.43
MEN1 known ✓ O00255 3/20 0.41
SLC6A2 known ✓ P23975 1/20 0.41
SLC6A4 known ✓ P31645 1/20 0.41
DRD3 known ✓ P35462 1/20 0.41
THRB known ✓ P10828 2/20 0.40
KDR known ✓ P35968 1/20 0.40
ALDH1A1 P00352 6/20 0.50
ALOX15 P16050 2/20 0.50
CYP1A2 P05177 1/20 0.50
CA1 P00915 4/20 0.43
CA2 P00918 4/20 0.43
CA12 O43570 3/20 0.43
CA7 P43166 3/20 0.43
CA9 Q16790 3/20 0.43
CA14 Q9ULX7 3/20 0.43
TSHR P16473 3/20 0.43
HSD17B10 Q99714 4/20 0.42
HPGD P15428 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyromellitic Acid SCHEMBL5969075 1.00 ALDH1A1 (0.50) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL28045608 1.00 ALDH1A1 (0.50) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL27593068 0.96 ALDH1A1 (0.47) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL22127 0.96 ALDH1A1 (0.53) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL22443 0.96 ALDH1A1 (0.53) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL2337892 0.92 ALDH1A1 (0.50) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL7732131 0.92 ALDH1A1 (0.50) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL21328420 0.92 ALDH1A1 (0.50) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL22982083 0.92 ALDH1A1 (0.50) ALDH1A1ALOX15CYP1A2CA1CA2
Pyromellitic Acid SCHEMBL7456153 0.92 ALDH1A1 (0.50) ALDH1A1ALOX15CYP1A2CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140356283-A1 Probes, Methods of Making Probes, and Methods of Use ENERGY, UNITED STATES DEPARTMENT OF 2014-12-04 US disclosed
US-8718520-B2 Intermediate transfer belt and image forming apparatus RICOH COMPANY, LTD. (JP) 2014-05-06 US disclosed
EP-1743174-B1 MULTIMODALITY NANOSTRUCTURES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF UNIV EMORY (US) 2013-03-20 EP disclosed
CN-102985550-A Compositions and methods for fermentation of biomass QTEROS INC 2013-03-20 CN disclosed
US-20130004212-A1 INTERMEDIATE TRANSFER BELT AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2013-01-03 US disclosed
EP-2421984-A1 COMPOSITIONS AND METHODS FOR FERMENTATION OF BIOMASS Qteros, Inc. (US) 2012-02-29 EP disclosed
WO-2010123932-A9 COMPOSITIONS AND METHODS FOR FERMENTATION OF BIOMASS QTEROS, INC. (US) 2011-06-09 WO disclosed
EP-2325642-A1 Use of multimodality nanostructures to detect target substances Emory University (US) 2011-05-25 EP disclosed
WO-2011002824-A1 PRETREATMENT OF BIOMASS QTEROS, INC. (US) 2011-01-06 WO disclosed
WO-2010123932-A1 COMPOSITIONS AND METHODS FOR FERMENTATION OF BIOMASS QTEROS, INC. (US) 2010-10-28 WO disclosed
US-20100268000-A1 Compositions and Methods for Fermentation of Biomass QTEROS, INC. (US) 2010-10-21 US disclosed
US-20080267882-A1 Multimeric RGD (arginine-glycine-aspartic acid (Arg-Gly-Asp)) peptide; positron emission tomography; angiogenesis; kits STANFORD UNIVERSITY (US) 2008-10-30 US disclosed
EP-1743174-A4 MULTIMODALITY NANOSTRUCTURES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF UNIV EMORY (US) 2008-08-20 EP disclosed
EP-1743174-A2 MULTIMODALITY NANOSTRUCTURES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF EMORY UNIVERSITY (US) 2007-01-17 EP disclosed
US-20050265922-A1 Multimodality nanostructures, methods of fabrication thereof, and methods of use thereof EMORY UNIVERSITY 2005-12-01 US disclosed
WO-2005102396-A2 MULTIMODALITY NANOSTRUCTURES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF EMORY UNIVERSITY (US) 2005-11-03 WO disclosed