Sugi Predict

Sugi Predict / Compounds / SCHEMBL6925588

SCHEMBL6925588

SCHEMBL6925588

NC1=CCc2ccccc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 1/20 0.48
▸ TSHR P16473 1/20 0.40
▸ NOS3 P29474 5/20 0.39
▸ NOS2 P35228 3/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ CHEK1 O14757 1/20 0.37
▸ DAPK3 O43293 1/20 0.37
▸ LTK P29376 1/20 0.37
▸ MAPK8 P45983 1/20 0.37
▸ CSNK1A1 P48729 1/20 0.37
▸ CDK8 P49336 1/20 0.37
▸ LIMK1 P53667 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30041622 1.00 HTR6 (0.48) HTR6TSHRNOS3NOS2ALDH1A1
SCHEMBL9321655 0.82 MAOA (0.50) HTR6ALDH1A1KDM4ENPC1LMNA
SCHEMBL6624132 0.82 HTR6 (0.43) HTR6TSHRNOS3NOS2ALDH1A1
SCHEMBL11229162 0.78 HTR6 (0.40) HTR6TSHRNOS3NOS2ALDH1A1
SCHEMBL29444072 0.76 NOS3 (0.45) TSHRNOS3NOS2ALDH1A1KDM4E
SCHEMBL3630867 0.76 NOS3 (0.45) TSHRNOS3NOS2ALDH1A1KDM4E
SCHEMBL10532536 0.76 ALDH1A1 (0.46) HTR6TSHRALDH1A1KDM4ELMNA
SCHEMBL26013515 0.73 ALDH1A1 (0.48) HTR6TSHRNOS3NOS2ALDH1A1
SCHEMBL7960264 0.72 HTR6 (0.41) HTR6TSHRALDH1A1L3MBTL1MAOA
SCHEMBL4448887 0.72 HTR6 (0.41) HTR6TSHRNOS3NOS2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117343703-A Branched epoxy resin pressure-bearing plugging material and oil-based drilling fluid 西南石油大学 2024-01-05 — — CN claimed
CN-110372519-B Synthetic method of 3-aminoindene compounds 浙江大学 2023-04-11 — — CN claimed
CN-110372519-A A kind of synthetic method of 3- amino indene compounds 浙江大学 2019-10-25 — — CN claimed
CN-117677622-A Sulfonyl imide amide compounds and uses thereof 基因泰克公司 2024-03-08 — — CN disclosed
CN-117343703-A Branched epoxy resin pressure-bearing plugging material and oil-based drilling fluid 西南石油大学 2024-01-05 — — CN disclosed
US-11858929-B2 Compounds and methods for inhibiting fascin CORNELL UNIVERSITY (US) 2024-01-02 — — US disclosed
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR NOVITA PHARMACEUTICALS, INC. (US) 2023-10-05 — — US disclosed
US-11701342-B2 Co-therapies including a metastasis inhibitor CORNELL UNIVERSITY (US) 2023-07-18 — — US disclosed
CN-110372519-B Synthetic method of 3-aminoindene compounds 浙江大学 2023-04-11 — — CN disclosed
CN-110372519-B Synthetic method of 3-aminoindene compounds 浙江大学 2023-04-11 — — CN disclosed
CN-115461120-A Sulfonylimide compounds as NLRP3 modulators 豪夫迈·罗氏有限公司 2022-12-09 — — CN disclosed
CN-110372519-A A kind of synthetic method of 3- amino indene compounds 浙江大学 2019-10-25 — — CN disclosed
US-20180215757-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2018-08-02 — — US disclosed
US-9850243-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-12-26 — — US disclosed
US-20170158692-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2017-06-08 — — US disclosed
US-9573946-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-02-21 — — US disclosed
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2015-10-22 — — US disclosed
EP-1281723-B1 NOVEL PROCESS FOR THE PRODUCTION OF POLYACETYLENE DERIVATIVES JAPAN SCIENCE & TECH AGENCY (JP) 2008-07-16 — — EP disclosed
US-6737547-B1 Compositions containing and methods of using N-acyl-1H-aminoindenes TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2004-05-18 — — US disclosed
WO-2000038673-A1 COMPOSITIONS CONTAINING AND METHODS OF USING N-ACYL-1H-AMINOINDENES TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2000-07-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF HTR6 2746/4885TSHR 4499/4885NOS3 3011/4885
US-11858929-B2 Compounds and methods for inhibiting fascin FSCN1, MTPN, MYOF HTR6 2746/4885TSHR 4499/4885NOS3 3011/4885
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR MIF, CXCL10, CCL2 HTR6 4706/4885TSHR 4046/4885NOS3 4242/4885
US-20180215757-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF HTR6 2746/4885TSHR 4499/4885NOS3 3011/4885
US-20170158692-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF HTR6 2746/4885TSHR 4499/4885NOS3 3011/4885
US-11701342-B2 Co-therapies including a metastasis inhibitor MIF, CXCL10, CCL2 HTR6 4706/4885TSHR 4046/4885NOS3 4242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.