Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.39 |
| ▸ | SELE | P16581 | 3/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930689 | 0.77 | MAPT (0.38) | L3MBTL1MAPTNPSR1POLBHTT | |
| SCHEMBL6927314 | 0.73 | CYP2A6 (0.43) | L3MBTL1MAPTNPSR1HTTICAM1 | |
| SCHEMBL989191 | 0.73 | NFKB1 (0.44) | L3MBTL1POLBHTTSMN1; SMN2TDP1 | |
| SCHEMBL8111349 | 0.72 | ALDH1A1 (0.39) | NPSR1ARTDP1MEN1KMT2A | |
| SCHEMBL28051461 | 0.71 | DHFR (0.43) | L3MBTL1MAPTNPSR1POLBHTT | |
| SCHEMBL6765841 | 0.69 | L3MBTL1 (0.48) | L3MBTL1MAPTNPSR1POLBHTT | |
| SCHEMBL30361071 | 0.69 | CA1 (0.43) | L3MBTL1SMN1; SMN2TDP1MEN1KMT2A | |
| SCHEMBL6926438 | 0.68 | MLYCD (0.43) | L3MBTL1MAPTNPSR1HTTICAM1 | |
| SCHEMBL6928332 | 0.68 | MLYCD (0.43) | L3MBTL1MAPTNPSR1HTTICAM1 | |
| SCHEMBL11121836 | 0.67 | CYP1A2 (0.53) | L3MBTL1MAPTNPSR1SMN1; SMN2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |