Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30644974 | 1.00 | GABRA1 (0.52) | GABRA1GABRB2MGLLCYP2D6TSHR | |
| SCHEMBL29390847 | 0.85 | GABRA1 (0.58) | GABRA1GABRB2MGLLCYP2D6ALDH1A1 | |
| SCHEMBL36294 | 0.85 | GABRA1 (0.58) | GABRA1GABRB2MGLLCYP2D6ALDH1A1 | |
| SCHEMBL29382225 | 0.85 | TSHR (0.50) | GABRA1GABRB2CYP2D6TSHRALDH1A1 | |
| SCHEMBL28289 | 0.85 | TSHR (0.50) | GABRA1GABRB2CYP2D6TSHRALDH1A1 | |
| SCHEMBL25425763 | 0.85 | GABRA1 (0.58) | GABRA1GABRB2MGLLCYP2D6ALDH1A1 | |
| SCHEMBL7542830 | 0.82 | GABRA1 (0.55) | GABRA1GABRB2MGLLCYP2D6ALDH1A1 | |
| SCHEMBL14807864 | 0.82 | GABRA1 (0.55) | GABRA1GABRB2MGLLCYP2D6ALDH1A1 | |
| Benzene SCHEMBL3122858 | 0.82 | TP53 (0.56) | GABRA1GABRB2MGLLCYP2D6TP53 | |
| Benzene SCHEMBL11603070 | 0.82 | TP53 (0.56) | GABRA1GABRB2MGLLCYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3750890-B1 | ALKOXYBENZO-FIVE-MEMBERED (SIX-MEMBERED) HETEROCYCLIC AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF | SHIJIAZHUANG YILING PHARMACEUTICAL CO LTD (CN) | 2026-04-01 | — | — | EP | disclosed |
| US-20260007672-A1 | INHIBITORS OF MPTP | NRG THERAPEUTICS LTD (GB) | 2026-01-08 | — | — | US | disclosed |
| US-12491185-B2 | Inhibitors of mPTP | NRG THERAPEUTICS LTD (GB) | 2025-12-09 | — | — | US | disclosed |
| EP-4652162-A1 | INHIBITORS OF MPTP | NRG Therapeutics LTD (GB) | 2025-11-26 | — | — | EP | disclosed |
| US-20250177397-A1 | INHIBITORS OF MPTP | NRG THERAPEUTICS LTD (GB) | 2025-06-05 | — | — | US | disclosed |
| WO-2025016469-A1 | ALKOXY THIOPHENE ACYL ARYLAMINE COMPOUNDS AND USE THEREOF | 复旦大学 | 2025-01-23 | — | — | WO | disclosed |
| CN-119320385-A | Alkoxy thiophene carboxamide compounds and application thereof | 复旦大学 | 2025-01-17 | — | — | CN | disclosed |
| US-20240327408-A1 | COMPOUNDS CONTAINING TETRAHYDRONAPHTHYRIDINONE OR TETRAHYDROPYRIDOPYRIMIDINONE SKELETON, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2024-10-03 | — | — | US | disclosed |
| EP-3615515-B1 | PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF | AVIARA PHARMACEUTICALS INC (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2024153946-A1 | INHIBITORS OF MPTP | NRG THERAPEUTICS LTD (GB) | 2024-07-25 | — | — | WO | disclosed |
| US-7030242-B2 | Selective inhibition of aggrecanase in osteoarthritis treatment | PFIZER INC (US) | 2006-04-18 | — | — | US | disclosed |
| US-20050227997-A1 | 1-[4-(2-methyl-benzyloxy)-benzenesulfonyl]-4-aminoacetyl-3-methyl-piperazine-2-carboxylic acid hydroxyamide; potent enzyme inhibitor of metalloproteinases, for treating joint disease, prevent cartilage destruction | NOE MARK C | 2005-10-13 | — | — | US | disclosed |
| EP-0637580-B1 | Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof | SUMITOMO CHEMICAL CO (JP) | 2002-08-14 | — | — | EP | disclosed |
| EP-1081137-A1 | Selective inhibitors of aggrecanase in osteoarthritis treatment | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| US-6063940-A | Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| US-5637736-A | Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-06-10 | — | — | US | disclosed |
| EP-0695303-A1 | NEW PYRIDINIUM SALTS AND THEIR USE FOR CONTROLLING HELICOBACTER BACTERIA | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1996-02-07 | — | — | EP | disclosed |
| EP-0637580-A1 | Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1995-02-08 | — | — | EP | disclosed |
| WO-1994024130-A1 | NEW PYRIDINIUM SALTS AND THEIR USE FOR CONTROLLING HELICOBACTER BACTERIA | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-10-27 | — | — | WO | disclosed |
| WO-1993013089-A1 | MACROCYCLIC POLYETHER CARBOXYLIC ACIDS | URBAN FRANK J (US) | 1993-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12491185-B2 | Inhibitors of mPTP | PARK7, PINK1, SNCA | GABRA1 604/4885GABRB2 243/4885MGLL 2476/4885 |
| US-20050227997-A1 | 1-[4-(2-methyl-benzyloxy)-benzenesulfonyl]-4-aminoacetyl-3-methyl-piperazine-2-carboxylic acid hydroxyamide; potent enzyme inhibitor of metalloproteinases, for treating joint disease, prevent cartilage destruction | MMP3, MMP1, MMP13 | GABRA1 2258/4885GABRB2 3050/4885MGLL 3375/4885 |
| US-20250177397-A1 | INHIBITORS OF MPTP | PARK7, PINK1, SNCA | GABRA1 604/4885GABRB2 243/4885MGLL 2476/4885 |
| US-20240327408-A1 | COMPOUNDS CONTAINING TETRAHYDRONAPHTHYRIDINONE OR TETRAHYDROPYRIDOPYRIMIDINONE SKELETON, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | PRCP, TMPRSS15, WEE1 | GABRA1 1859/4885GABRB2 2679/4885MGLL 3697/4885 |
| US-20260007672-A1 | INHIBITORS OF MPTP | PARK7, SNCA, CYC1 | GABRA1 439/4885GABRB2 262/4885MGLL 2961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.