Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931877 | 0.87 | THRB (0.48) | MAPTGAATHRBBLMGFER | |
| SCHEMBL8822110 | 0.87 | ALDH1A1 (0.51) | MAPTGAABLMKDM4ESMN1; SMN2 | |
| SCHEMBL6937152 | 0.84 | CA1 (0.40) | THRBBLMSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7783570 | 0.84 | DHODH (0.63) | MAPTTHRBBLMSMN1; SMN2NPC1 | |
| SCHEMBL6936296 | 0.84 | RAB9A (0.39) | THRBBLMSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10643669 | 0.82 | NPC1 (0.38) | THRBBLMSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10648551 | 0.81 | SMN1; SMN2 (0.44) | MAPTTHRBBLMSMN1; SMN2NPC1 | |
| SCHEMBL10646741 | 0.79 | DHODH (0.43) | MAPTTHRBBLMTDP1SMN1; SMN2 | |
| SCHEMBL10644685 | 0.77 | NPC1 (0.41) | THRBBLMSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8812360 | 0.75 | RAB9A (0.70) | MAPTTHRBBLMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859000-B1 | Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof | AVENTIS PHARMA GMBH (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-0859000-A1 | Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-19 | — | — | EP | disclosed |