Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936296 | 0.87 | RAB9A (0.39) | NPC1RAB9ADHODHSMN1; SMN2GMNN | |
| SCHEMBL6931877 | 0.85 | THRB (0.48) | NPC1RAB9ADHODHSMN1; SMN2GMNN | |
| SCHEMBL6932048 | 0.84 | MAPT (0.46) | CA1CA2NPC1RAB9ADHODH | |
| SCHEMBL8822110 | 0.82 | ALDH1A1 (0.51) | NPC1RAB9ASMN1; SMN2HTTBLM | |
| SCHEMBL7783570 | 0.80 | DHODH (0.63) | NPC1RAB9ADHODHSMN1; SMN2GMNN | |
| SCHEMBL10648551 | 0.79 | SMN1; SMN2 (0.44) | NPC1RAB9ADHODHSMN1; SMN2GMNN | |
| SCHEMBL10643669 | 0.78 | NPC1 (0.38) | NPC1RAB9ADHODHSMN1; SMN2GMNN | |
| SCHEMBL10646741 | 0.77 | DHODH (0.43) | NPC1RAB9ADHODHSMN1; SMN2GMNN | |
| SCHEMBL10644685 | 0.76 | NPC1 (0.41) | NPC1RAB9ADHODHSMN1; SMN2GMNN | |
| SCHEMBL16531459 | 0.71 | HTR2A (0.66) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859000-B1 | Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof | AVENTIS PHARMA GMBH (DE) | 2003-01-22 | — | — | EP | claimed |
| EP-0859000-A1 | Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-19 | — | — | EP | claimed |
| EP-0859000-B1 | Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof | AVENTIS PHARMA GMBH (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-0859000-A1 | Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-19 | — | — | EP | disclosed |