Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPR3 | P17342 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941574 | 0.87 | ADAM17 (0.38) | MMP1MMP3MMP9ADAM17 | |
| SCHEMBL6942324 | 0.80 | CREBBP (0.31) | MMP1MMP3 | |
| SCHEMBL6940308 | 0.79 | MMP1 (0.41) | MMP1MMP3MMP9CTSKADAM17 | |
| SCHEMBL6939987 | 0.74 | NPC1 (0.33) | MAPTTDP1ADAM17 | |
| SCHEMBL7076167 | 0.72 | ADAM17 (0.39) | MMP1MMP3MMP9ADAM17 | |
| SCHEMBL6943182 | 0.72 | CTSC (0.34) | MAPTADAM17 | |
| SCHEMBL7940341 | 0.69 | F10 (0.32) | MMP1MAPTNTSR1NPSR1TDP1 | |
| SCHEMBL6941637 | 0.68 | NPC1 (0.34) | CTSKMAPTNTSR1NPSR1TDP1 | |
| SCHEMBL6944592 | 0.67 | NPC1 (0.38) | MMP3ADAM17 | |
| SCHEMBL6947988 | 0.67 | ALDH1A1 (0.37) | MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |