Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | ANPEP | P15144 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | LAP3 | P28838 | 1/20 | 0.33 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | MASP2 | O00187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819016 | 0.90 | TGFBR1 (0.32) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL7933475 | 0.88 | CTSK (0.32) | TGFBR1P2RX3 | |
| SCHEMBL7955132 | 0.82 | ADAM17 (0.44) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL7835552 | 0.82 | ADAM17 (0.44) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL7928806 | 0.82 | P2RX3 (0.34) | ADAM17TGFBR1P2RX3CTSCMASP2 | |
| SCHEMBL6944688 | 0.80 | P2RX3 (0.31) | TGFBR1P2RX3CTSC | |
| SCHEMBL8112771 | 0.79 | SLC6A3 (0.31) | ADAM17TGFBR1P2RX3 | |
| SCHEMBL7930219 | 0.79 | TGFBR1 (0.31) | TGFBR1P2RX3CTSCMASP2 | |
| SCHEMBL7933480 | 0.77 | KDM4E (0.33) | TGFBR1 | |
| SCHEMBL6941960 | 0.76 | ADAM17 (0.33) | ADAM17TGFBR1P2RX3CTSCMASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |