Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944688 | 0.91 | P2RX3 (0.31) | TGFBR1 | |
| SCHEMBL7933428 | 0.80 | P2RX3 (0.33) | SLC6A3TGFBR1 | |
| SCHEMBL7933475 | 0.79 | CTSK (0.32) | MEN1KMT2AALDH1A1GAACTSK | |
| SCHEMBL6944685 | 0.77 | ADAM17 (0.34) | TGFBR1 | |
| SCHEMBL7819016 | 0.76 | TGFBR1 (0.32) | TGFBR1 | |
| SCHEMBL6983937 | 0.76 | ADAM17 (0.42) | ALDH1A1CTSKSLC6A3TGFBR1 | |
| SCHEMBL7930228 | 0.74 | CTSC (0.33) | SLC6A3TGFBR1 | |
| SCHEMBL6941960 | 0.74 | ADAM17 (0.33) | MEN1KMT2AALDH1A1GAATGFBR1 | |
| SCHEMBL7928806 | 0.74 | P2RX3 (0.34) | ALDH1A1GAASLC6A3TGFBR1 | |
| SCHEMBL7937958 | 0.74 | P2RX3 (0.31) | MCHR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |