Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942710 | 0.91 | ADAM17 (0.46) | ADAM17GAAMMP1MMP2MMP3 | |
| SCHEMBL6982398 | 0.88 | CHRNB2 (0.45) | CHRNB2CHRNA4ADAM17RAB9AMMP1 | |
| SCHEMBL6944086 | 0.82 | ADAM17 (0.42) | ADAM17GAAMMP1MMP2MMP3 | |
| SCHEMBL6941589 | 0.82 | ADAM17 (0.49) | CHRNB2CHRNA4ADAM17RAB9AGAA | |
| SCHEMBL6947136 | 0.80 | ADAM17 (0.44) | ADAM17RAB9AGAAMMP1MMP2 | |
| SCHEMBL6942460 | 0.80 | ADAM17 (0.46) | ADAM17MMP1MMP2MMP3MMP7 | |
| SCHEMBL6220493 | 0.78 | ADAM17 (0.48) | ADAM17MAPTMAPK1KMT2AATM | |
| SCHEMBL6220502 | 0.78 | ADAM17 (0.48) | ADAM17MAPTMAPK1KMT2AATM | |
| SCHEMBL6984686 | 0.78 | ADAM17 (0.48) | ADAM17MAPTMAPK1KMT2AATM | |
| SCHEMBL6220496 | 0.78 | ADAM17 (0.48) | ADAM17MAPTMAPK1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |