Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815345 | 0.92 | NFE2L2 (0.33) | ACHEPTGS2PTGS1GABRPGABRD | |
| SCHEMBL25097 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1BCL2L1 | |
| SCHEMBL769959 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1BCL2L1 | |
| SCHEMBL769634 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1BCL2L1 | |
| SCHEMBL41140 | 0.80 | ALDH1A1 (0.42) | NPC1RAB9AALDH1A1BCL2L1MEN1 | |
| SCHEMBL38202 | 0.80 | ALDH1A1 (0.42) | NPC1RAB9AALDH1A1BCL2L1MEN1 | |
| SCHEMBL183516 | 0.80 | ALDH1A1 (0.35) | RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL3537375 | 0.80 | CYP1A2 (0.33) | — | |
| SCHEMBL27647876 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1KMT2A | |
| SCHEMBL67548 | 0.77 | ACHE (0.38) | ACHETNKSPARP1TNKS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106589349-B | Bi-phthalonitrile resin of main chain s-triazine structure containing triaryl and preparation method thereof | 大连理工大学 | 2019-01-08 | — | — | CN | claimed |
| CN-105175336-B | A kind of carboxamides derivatives of 3 (3,3 2 chloroallyloxyamino) 1 Phenylpyrazole 5 and preparation method thereof | 南阳师范学院 | 2017-11-03 | — | — | CN | claimed |
| CN-105175335-B | A kind of carboxamides derivatives of 3 (3,3 2 chloroallyloxyamino) 1 methylpyrazole 5 and preparation method thereof | 南阳师范学院 | 2017-11-03 | — | — | CN | claimed |
| CN-105061396-B | A kind of amide derivatives and preparation method thereof | 南阳师范学院 | 2017-09-15 | — | — | CN | claimed |
| EP-2504324-B1 | SULTAM DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-02-25 | — | — | EP | claimed |
| US-8946479-B2 | Process for preparation of 4-fluoro-α-[2methyl-l-oxopropyl]-γ-oxo—N—β-diphenylbenzene butane amide | VIJAYASRI ORGANICS LIMITED (IN) | 2015-02-03 | — | — | US | claimed |
| US-20130184493-A1 | PROCESS FOR PREPARATION OF 4-FLUORO-alpha-[2METHYL-L-OXOPROPYL]-gamma-OXO-N-beta-DIPHENYLBENZENE BUTANE AMIDE | VIJAYASRI ORGANICS LIMITED (IN) | 2013-07-18 | — | — | US | claimed |
| US-8362001-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-29 | — | — | US | claimed |
| US-8314250-B2 | Sultam derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-11-20 | — | — | US | claimed |
| EP-2504324-A1 | SULTAM DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-03 | — | — | EP | claimed |
| US-20030236410-A1 | Pharmaceutical composition containing bicyclic type compounds | SMITHKLINE BEECHAM P.L.C. | 2003-12-25 | — | — | US | claimed |
| WO-2003022842-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-20 | — | — | WO | claimed |
| US-20020123630-A1 | Pharmaceutical composition containing bicyclic type compounds | SMITHKLINE BEECHAM P.L.C. | 2002-09-05 | — | — | US | claimed |
| EP-0895988-B1 | Arylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2002-05-22 | — | — | EP | claimed |
| US-20010021780-A1 | Pharmaceutical composition containing bicyclic type compounds | SMITHKLINE BEECHAM P.L.C. | 2001-09-13 | — | — | US | claimed |
| US-6107337-A | ANTIARTHRITIC AGENTS; ANTICARCINOGENIC AGENTS | PFIZER INC. (US) | 2000-08-22 | — | — | US | claimed |
| EP-0895988-A1 | Arylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-02-10 | — | — | EP | claimed |
| EP-0673374-A1 | PHARMACEUTICAL COMPOSITION CONTAINING BICYCLIC TYPE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1995-09-27 | — | — | EP | claimed |
| WO-1994013657-A1 | PHARMACEUTICAL COMPOSITION CONTAINING BICYCLIC TYPE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-23 | — | — | WO | claimed |
| US-5110959-A | PROCESS FOR PREPARATION OF EPOXY ESTERS AND INTERMEDIATES PREPARED THEREBY | SMITHKLINE BECKMAN CORP. (US) | 1992-05-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236410-A1 | Pharmaceutical composition containing bicyclic type compounds | CLIC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP2B6 | ACHE 4078/4885PTGS2 2521/4885PTGS1 1127/4885 |
| US-20130184493-A1 | PROCESS FOR PREPARATION OF 4-FLUORO-alpha-[2METHYL-L-OXOPROPYL]-gamma-OXO-N-beta-DIPHENYLBENZENE BUTANE AMIDE | BCKDK, FNTB, HMGCR | ACHE 1957/4885PTGS2 2093/4885PTGS1 2114/4885 |
| US-20010021780-A1 | Pharmaceutical composition containing bicyclic type compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CLIC1, NAF1 | ACHE 4121/4885PTGS2 2145/4885PTGS1 925/4885 |
| US-20020123630-A1 | Pharmaceutical composition containing bicyclic type compounds | CLIC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CFH | ACHE 4050/4885PTGS2 2555/4885PTGS1 1191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.