Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30496795 | 0.85 | TDP1 (0.66) | TDP1AKR1B1LMNAPTGS1AKR1C3 | |
| SCHEMBL4202279 | 0.83 | LMNA (0.43) | AKR1B1LMNATP53ATMMTNR1A | |
| SCHEMBL20099484 | 0.83 | TDP1 (0.49) | TDP1AKR1B1ATMPTGS1AKR1C3 | |
| SCHEMBL21585547 | 0.82 | TDP1 (0.62) | TDP1AKR1B1FFAR1SLC22A12THRA | |
| SCHEMBL22279217 | 0.82 | TDP1 (0.48) | TDP1AKR1B1ATMPTGS1AKR1C3 | |
| SCHEMBL31429834 | 0.79 | MTNR1A (0.61) | TDP1PTGS1AKR1C3AKR1C2PPARD | |
| SCHEMBL7925457 | 0.79 | MTNR1A (0.61) | TDP1PTGS1AKR1C3AKR1C2PPARD | |
| SCHEMBL21585560 | 0.79 | TDP1 (0.66) | TDP1AKR1B1LMNATHRATHRB | |
| SCHEMBL14564415 | 0.77 | TDP1 (0.64) | TDP1AKR1B1LMNASLC22A12L3MBTL1 | |
| SCHEMBL19019569 | 0.77 | TDP1 (0.55) | TDP1AKR1B1SLC22A12PPARDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030207919-A1 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use | NICOX S.A. (FR) | 2003-11-06 | — | — | US | disclosed |
| US-6433007-B1 | APPLYING BENZOFURAN OR BENZOPYRAN DERIVATIVE WITH NON-STEROIDAL ANTIINFLAMMATORY MOIETY OPHTHALMIC SOLUTION | ALCON MANUFACTURING, LTD. | 2002-08-13 | — | — | US | disclosed |
| US-6242243-B1 | PURE CULTURE; FOR PRODUCTION OF HYDROLASE ENZYME USEFUL IN EFFICIENT RESOLUTION OF (+)-6-METHOXY-ALPHA-METHYL NAPHTHALENE ACETIC ACID ALKYL ESTERS; PRODUCTION OF NAPROXEN | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2001-06-05 | — | — | US | disclosed |
| WO-2000035420-A2 | STABLE SURGICAL IRRIGATING SOLUTIONS | ALCON LABORATORIES, INC. (US) | 2000-06-22 | — | — | WO | disclosed |
| WO-2000035433-A2 | METHODS FOR THE PREVENTION AND TREATMENT OF POST-SURGICAL COMPLICATIONS | ALCON LABORATORIES, INC. (US) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207919-A1 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use | NOS2, NOS1, NOS3 | TDP1 1306/4885AKR1B1 203/4885LMNA 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.