Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 6/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194360 | 0.82 | MTNR1A (0.73) | MTNR1AMTNR1BNQO2AKR1C3ROCK1 | |
| SCHEMBL8717495 | 0.82 | HTR6 (0.62) | MTNR1AMTNR1BNQO2HTR6ADRB2 | |
| SCHEMBL6938945 | 0.81 | MTNR1A (0.58) | MTNR1AMTNR1BNQO2AKR1C3 | |
| SCHEMBL6833442 | 0.81 | ADRB2 (0.67) | MTNR1AMTNR1BNQO2HTR6ADRB2 | |
| SCHEMBL6944686 | 0.81 | MTNR1A (0.57) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL6939654 | 0.81 | MTNR1A (0.57) | MTNR1AMTNR1BNQO2AKR1C3ROCK1 | |
| SCHEMBL6921659 | 0.79 | HTR6 (0.68) | MTNR1AHTR6 | |
| SCHEMBL7122186 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1BNQO2HTR6AKR1C3 | |
| SCHEMBL6944873 | 0.78 | MTNR1A (0.54) | MTNR1AMTNR1BNQO2AKR1C3ROCK1 | |
| SCHEMBL6919423 | 0.74 | HTR6 (0.53) | MTNR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004085395-A1 | MELATONIN DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL DYSFUNCTIONS | FAUST PHARMACEUTICALS (FR) | 2004-10-07 | — | — | WO | disclosed |