Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952538 | 0.97 | FAAH (0.44) | FAAHMAPTNLRP3CYP3A4TP53 | |
| SCHEMBL6953443 | 0.90 | NLRP3 (0.45) | FAAHMAPTNLRP3CYP3A4PTAFR | |
| SCHEMBL6358943 | 0.85 | FOLH1 (0.48) | FAAHMAPTCYP3A4PTAFRFOLH1 | |
| SCHEMBL6954777 | 0.85 | FOLH1 (0.47) | FAAHMAPTCYP3A4PTAFRFOLH1 | |
| SCHEMBL7393082 | 0.85 | FLT4 (0.46) | FAAHNLRP3CYP3A4LMNATSHR | |
| SCHEMBL6950532 | 0.83 | L3MBTL1 (0.41) | NLRP3CYP3A4TP53LMNAKMT2A | |
| SCHEMBL8496788 | 0.80 | CYP3A4 (0.64) | FAAHMAPTCYP3A4MAPK1PTAFR | |
| SCHEMBL7835677 | 0.79 | GPR132 (0.42) | MAPTTP53ALDH1A1 | |
| SCHEMBL7825812 | 0.78 | TP53 (0.39) | MAPTNLRP3TP53NPC1LMNA | |
| SCHEMBL9394451 | 0.78 | KMT2A (0.48) | NLRP3KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804418-B1 | PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2003-03-26 | — | — | EP | claimed |
| US-5639765-A | OSTEOPOROSIS, PAGET*S DISEASE | G. D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | claimed |
| US-5602155-A | GUANIDINO ALKYL AND PYRIDINE CARBOXYLATE SUBSTITUTED AMIDES | G. D. SEARLE & CO. (US) | 1997-02-11 | — | — | US | claimed |
| WO-1996023771-A2 | PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1996-08-08 | — | — | WO | claimed |
| EP-0804418-B1 | PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2003-03-26 | — | — | EP | disclosed |
| US-5639765-A | OSTEOPOROSIS, PAGET*S DISEASE | G. D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5602155-A | GUANIDINO ALKYL AND PYRIDINE CARBOXYLATE SUBSTITUTED AMIDES | G. D. SEARLE & CO. (US) | 1997-02-11 | — | — | US | disclosed |
| WO-1996023771-A2 | PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1996-08-08 | — | — | WO | disclosed |