Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11599874 | 0.84 | LMNA (0.41) | PARP1TERTSMN1; SMN2ACHEMEN1 | |
| SCHEMBL6965685 | 0.80 | TPMT (0.43) | MEN1KMT2ALMNAHSD17B10 | |
| SCHEMBL7376137 | 0.80 | ALDH1A1 (0.44) | ALOX5PPARGPPARALMNAHSD17B10 | |
| SCHEMBL6958711 | 0.78 | CYP2C9 (0.43) | KIF11PARP1TERTMEN1KMT2A | |
| SCHEMBL6965136 | 0.78 | LMNA (0.46) | SMN1; SMN2LMNAHSD17B10POLB | |
| SCHEMBL6962874 | 0.77 | MTNR1A (0.56) | PARP1LMNA | |
| SCHEMBL13562371 | 0.74 | ACHE (0.48) | TERTSMN1; SMN2ACHE | |
| SCHEMBL6956928 | 0.74 | CES2 (0.47) | SMN1; SMN2MEN1KMT2APPARGPPARA | |
| SCHEMBL27347338 | 0.73 | SLC22A12 (0.43) | PARP1TERTSMN1; SMN2ACHEMEN1 | |
| SCHEMBL12778511 | 0.72 | ACHE (0.46) | TERTSMN1; SMN2ACHEKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |