Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376137 | 0.84 | ALDH1A1 (0.44) | ALOX5MAPTGAAALDH1A1NPSR1 | |
| SCHEMBL7371129 | 0.81 | MTNR1B (0.54) | ALDH1A1MAPK1 | |
| SCHEMBL8329718 | 0.80 | PIN1 (0.50) | MAPTNPC1ALDH1A1 | |
| SCHEMBL6958711 | 0.77 | CYP2C9 (0.43) | MAPTGRM5GAANPC1ALDH1A1 | |
| SCHEMBL7371798 | 0.77 | EPHX1 (0.53) | MAPTGAANPC1ALDH1A1NPSR1 | |
| SCHEMBL1223851 | 0.76 | MAPT (0.61) | ALOX12ALOX5MAPTALDH1A1TRPM5 | |
| SCHEMBL5847126 | 0.74 | NPSR1 (0.47) | MAPTGAANPC1ALDH1A1NPSR1 | |
| SCHEMBL1224992 | 0.74 | TRPM5 (0.54) | GRM5NPC1ALDH1A1TRPM5ALOX15 | |
| SCHEMBL9052329 | 0.73 | MMP8 (0.50) | MAPTGRM5GAATRPV1NPC1 | |
| SCHEMBL12694091 | 0.72 | ITGB3 (0.49) | MAPTGAANPC1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |