Sugi Predict

Sugi Predict / Compounds / SCHEMBL695946

SCHEMBL695946

SCHEMBL695946

CC(C)(C)OC(=O)[C@@H]1C[C@@H](O)CN1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 4/20 0.41
▸ DPP8 Q6V1X1 4/20 0.41
▸ DPP9 Q86TI2 4/20 0.41
▸ CHRM2 P08172 1/20 0.39
▸ CHRM1 P11229 1/20 0.39
▸ CHRM3 P20309 1/20 0.39
▸ SMYD3 Q9H7B4 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ CYP1A2 P05177 1/20 0.31
▸ CYP2D6 P10635 1/20 0.31
▸ ALOX15 P16050 1/20 0.31
▸ CYP2C19 P33261 1/20 0.31
▸ SLC1A3 P43003 1/20 0.31
▸ SLC1A2 P43004 1/20 0.31
▸ SLC1A1 P43005 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29308170 1.00 DPP4 (0.41) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL21673908 1.00 DPP4 (0.41) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL28146362 1.00 DPP4 (0.41) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL4017978 1.00 DPP4 (0.41) DPP4DPP8DPP9CHRM2CHRM1
Hydrochloric Acid SCHEMBL30914110 0.98 DPP4 (0.40) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL4463526 0.86 DPP4 (0.37) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL3997238 0.86 DPP4 (0.37) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL9949501 0.84 CHRM2 (0.41) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL9949495 0.84 CHRM2 (0.41) DPP4DPP8DPP9CHRM2CHRM1
SCHEMBL4559703 0.82 DPP4 (0.38) DPP4DPP8DPP9CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4960881-A REACTING AMINO ACID WITH ALPHA-CHLORINATED CARBONATE IN SOLVENT IN PRESENCE OF ACID SCAVENGER SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) 1990-10-02 — — US claimed
EP-4153310-B1 BBETA-15-42 FOR THE TREATMENT OF VIRAL ENDOTHELITIS F4 PHARMA GMBH (AT) 2026-02-18 — — EP disclosed
US-20250064945-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE GENENTECH, INC. 2025-02-27 — — US disclosed
US-20250059198-A1 BRM DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE GENENTECH, INC. 2025-02-20 — — US disclosed
EP-4436966-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2024-10-02 — — EP disclosed
EP-4436965-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2024-10-02 — — EP disclosed
CN-118679160-A BRM targeting compounds and related methods of use 阿维纳斯运营公司 2024-09-20 — — CN disclosed
CN-118574827-A BRM targeting compounds and related methods of use 阿维纳斯运营公司 2024-08-30 — — CN disclosed
WO-2023096987-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2023-06-01 — — WO disclosed
WO-2023097031-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2023-06-01 — — WO disclosed
EP-2421826-A1 PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS F. Hoffmann-La Roche AG (CH) 2012-02-29 — — EP disclosed
WO-2010121918-A1 PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2010-10-28 — — WO disclosed
US-20100267722-A1 NOVEL PROLINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2010-10-21 — — US disclosed
US-20060241017-A1 Novel compounds with high therapeutic index SIGNATURE R&D HOLDINGS, LLC 2006-10-26 — — US disclosed
US-6541638-B2 (2S,4S)-1-(4-Mercapto-1-(naphthalene-2-sulfonyl)-pyrrolidine-2 -carbonyl)-piperidine-4-carboxylic acid ethyl ester for example; zinc protease inhibitors; for treating diseases associated with vasoconstriction HOFFMAN-LA ROCHE INC. 2003-04-01 — — US disclosed
US-20020049243-A1 Pyrrolidine derivatives HOFFMANN-LA ROCHE INC. 2002-04-25 — — US disclosed
US-5965556-A KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1999-10-12 — — US disclosed
US-5756763-A ENZYME INHIBITOR ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1998-05-26 — — US disclosed
EP-0709373-A1 NOVEL PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1996-05-01 — — EP disclosed
US-4960881-A REACTING AMINO ACID WITH ALPHA-CHLORINATED CARBONATE IN SOLVENT IN PRESENCE OF ACID SCAVENGER SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) 1990-10-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250059198-A1 BRM DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, RBX1, BRAP DPP4 4485/4885DPP8 3280/4885DPP9 3920/4885
US-20100267722-A1 NOVEL PROLINE DERIVATIVES PRAP1, PRR12, SLC6A7 DPP4 413/4885DPP8 791/4885DPP9 756/4885
US-20250064945-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, BRAP, VHL DPP4 4635/4885DPP8 3581/4885DPP9 4031/4885
US-20020049243-A1 Pyrrolidine derivatives PREP, PEPD, DNPEP DPP4 42/4885DPP8 77/4885DPP9 29/4885
US-20060241017-A1 Novel compounds with high therapeutic index IL4I1, SLC7A1, GOT1 DPP4 27/4885DPP8 34/4885DPP9 73/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.