SCHEMBL6960435

SCHEMBL6960435

CC(C)C(c1ccccn1)c1nc(COCc2ccccc2)[nH]c1Sc1cc(Cl)cc(Cl)c1

nearest known ligand 0.31

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.31
CHRM2 P08172 2/20 0.30
CHRM5 P08912 2/20 0.30
CHRM1 P11229 2/20 0.30
ADRA2B P18089 2/20 0.30
SLC6A2 P23975 2/20 0.30
HRH2 P25021 2/20 0.30
HTR2A P28223 2/20 0.30
SLC6A4 P31645 2/20 0.30
HRH1 P35367 2/20 0.30
SLC6A3 Q01959 2/20 0.30
KCNH2 Q12809 2/20 0.30
HRH3 Q9Y5N1 2/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C9 P11712 1/20 0.30
TSHR P16473 1/20 0.30
NFKB1 P19838 1/20 0.30
THPO P40225 1/20 0.30
RAB9A P51151 1/20 0.30
ADRA1A P35348 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5853119 0.86 TACR1 (0.34) TACR1
SCHEMBL6975006 0.85 CXCR4 (0.33) CHRM2CHRM5CHRM1ADRA2BSLC6A2
SCHEMBL6967039 0.85 KCNA5 (0.32) CHRM2CHRM5CHRM1ADRA2BSLC6A2
SCHEMBL5852619 0.84 TACR1 (0.34) TSHRRAB9AL3MBTL1TACR1
SCHEMBL6966027 0.84 XIAP (0.33) CYP2C9RAB9AL3MBTL1
SCHEMBL6968773 0.80 ADAMTS5 (0.34) TACR1
SCHEMBL6972964 0.77 GSK3B (0.37) HRH3L3MBTL1TACR1
SCHEMBL6964698 0.77 LMNA (0.36) HCAR2SLC6A2SLC6A4SLC6A3CYP2C9
SCHEMBL6971891 0.76 ALDH1A1 (0.37) HCAR2HRH3L3MBTL1TACR1
SCHEMBL6962307 0.75 CYP1A2 (0.35) HCAR2CYP2D6CYP2C9RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed