SCHEMBL6971891

SCHEMBL6971891

CC(C)c1nc(CCOCc2ccccc2)[nH]c1Sc1cc(Cl)cc(Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.37
TACR1 P25103 3/20 0.33
CAPN1 P07384 1/20 0.33
HCAR2 Q8TDS4 2/20 0.32
TDP1 Q9NUW8 2/20 0.31
GSK3B P49841 2/20 0.31
TUBB4A P04350 1/20 0.31
TUBB P07437 1/20 0.31
TUBA3C P0DPH7 1/20 0.31
TUBA1B P68363 1/20 0.31
TUBA4A P68366 1/20 0.31
TUBB4B P68371 1/20 0.31
TUBB3 Q13509 1/20 0.31
TUBB2A Q13885 1/20 0.31
TUBB8 Q3ZCM7 1/20 0.31
TUBA3E Q6PEY2 1/20 0.31
TUBA1A Q71U36 1/20 0.31
TUBA1C Q9BQE3 1/20 0.31
TUBB6 Q9BUF5 1/20 0.31
TUBB2B Q9BVA1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6971468 0.94 HRH4 (0.36) ALDH1A1TACR1CAPN1TDP1GSK3B
SCHEMBL5852619 0.90 TACR1 (0.34) TACR1CAPN1TDP1L3MBTL1DHODH
SCHEMBL6964698 0.82 LMNA (0.36) TACR1HCAR2TDP1
SCHEMBL6972964 0.81 GSK3B (0.37) TACR1TDP1GSK3BL3MBTL1HRH4
SCHEMBL6962307 0.80 CYP1A2 (0.35) ALDH1A1HCAR2TDP1DHODHMMP13
SCHEMBL14439826 0.79 TSHR (0.39) ALDH1A1CAPN1HCAR2
SCHEMBL14001863 0.78 HSP90B1 (0.31)
SCHEMBL27391656 0.78 ALDH1A1 (0.36) ALDH1A1TACR1CAPN1HCAR2TDP1
SCHEMBL6974600 0.78 TSHR (0.33) ALDH1A1TACR1CAPN1DHODH
SCHEMBL6968773 0.77 ADAMTS5 (0.34) ALDH1A1TACR1MMP2MMP13ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed